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Clinical characteristics of responders to intravitreal bevacizumab in central serous chorioretinopathy patients

Authors
 G A Kim  ;  T H Rim  ;  S C Lee  ;  S H Byeon  ;  H J Koh  ;  S S Kim  ;  C S Lee 
Citation
 Eye, Vol.29(6) : 732-741, 2015 
Journal Title
 Eye 
ISSN
 0950-222X 
Issue Date
2015
Abstract
PURPOSE: To investigate factors associated with good response to intravitreal bevacizumab (IVB) in central serous chorioretinopathy (CSC) patients. METHODS: We retrospectively reviewed 42 eyes of CSC patients of symptom duration more than 3 months who received a single or multiple successive IVBs on an as-needed basis (0.05 ml, 1.25 mg). High responders (HRs) were defined as complete resolution of subretinal fluid (SRF) on spectral domain optical coherence tomography (SD-OCT). Moderate responders (MRs) were defined as SRF resolution of 50-99% of pretreatment volume and poor responders (PRs) as SRF resolution <50%. Clinical, SD-OCT, fluorescein, and indocyanine green angiography findings were analyzed to find factors associated with HR. Descriptive statistics for all demographic and clinical variables were calculated, and comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U-test for means with continuous data, Pearson's χ(2) test, and Fisher's exact test for categorical data. RESULTS: The mean number of IVB was 1.9. At postoperative 1 month, there were 10 (24%) HRs, 18 (43%) MRs, and 14 (33%) PRs. At the last follow-up (the mean 8.6 months), there were 25 HRs (60%), 9 MRs (21%), and 8 PRs (19%). Thicker subfoveal choroid (P=0.036), smaller lesion diameter (P=0.019), and better baseline best-corrected visual acuity (P=0.002) predicted HRs at postoperative 1 month. HR at the last follow-up was associated with classic pattern fluorescein angiography finding. CONCLUSIONS: Suboptimal effects of IVB on persistent CSC suggest primary IVB on selective cases with better vision, smaller lesion, and thicker choroid at baseline.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141287
DOI
10.1038/eye.2015.58
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
고형준(Koh, Hyoung Jun) ; 김규아(Kim, Gyuah) ; 김성수(Kim, Sung Soo) ; 변석호(Byeon, Suk Ho) ; 이성철(Lee, Sung Chul) ; 이승규(Lee, Christopher Seungkyu) ; 임형택(Rim, Tyler Hyungtaek)
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http://www.nature.com/eye/journal/v29/n6/full/eye201558a.html
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