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Clinical characteristics of responders to intravitreal bevacizumab in central serous chorioretinopathy patients

DC FieldValueLanguage
dc.contributor.author고형준-
dc.contributor.author김규아-
dc.contributor.author김성수-
dc.contributor.author변석호-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author임형택-
dc.date.accessioned2016-02-04T11:49:31Z-
dc.date.available2016-02-04T11:49:31Z-
dc.date.issued2015-
dc.identifier.issn0950-222X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141287-
dc.description.abstractPURPOSE: To investigate factors associated with good response to intravitreal bevacizumab (IVB) in central serous chorioretinopathy (CSC) patients. METHODS: We retrospectively reviewed 42 eyes of CSC patients of symptom duration more than 3 months who received a single or multiple successive IVBs on an as-needed basis (0.05 ml, 1.25 mg). High responders (HRs) were defined as complete resolution of subretinal fluid (SRF) on spectral domain optical coherence tomography (SD-OCT). Moderate responders (MRs) were defined as SRF resolution of 50-99% of pretreatment volume and poor responders (PRs) as SRF resolution <50%. Clinical, SD-OCT, fluorescein, and indocyanine green angiography findings were analyzed to find factors associated with HR. Descriptive statistics for all demographic and clinical variables were calculated, and comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U-test for means with continuous data, Pearson's χ(2) test, and Fisher's exact test for categorical data. RESULTS: The mean number of IVB was 1.9. At postoperative 1 month, there were 10 (24%) HRs, 18 (43%) MRs, and 14 (33%) PRs. At the last follow-up (the mean 8.6 months), there were 25 HRs (60%), 9 MRs (21%), and 8 PRs (19%). Thicker subfoveal choroid (P=0.036), smaller lesion diameter (P=0.019), and better baseline best-corrected visual acuity (P=0.002) predicted HRs at postoperative 1 month. HR at the last follow-up was associated with classic pattern fluorescein angiography finding. CONCLUSIONS: Suboptimal effects of IVB on persistent CSC suggest primary IVB on selective cases with better vision, smaller lesion, and thicker choroid at baseline.-
dc.description.statementOfResponsibilityopen-
dc.format.extent732~740,quiz 741-
dc.relation.isPartOfEye-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical characteristics of responders to intravitreal bevacizumab in central serous chorioretinopathy patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorG A Kim-
dc.contributor.googleauthorT H Rim-
dc.contributor.googleauthorS C Lee-
dc.contributor.googleauthorS H Byeon-
dc.contributor.googleauthorH J Koh-
dc.contributor.googleauthorS S Kim-
dc.contributor.googleauthorC S Lee-
dc.identifier.doi10.1038/eye.2015.58-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00571-
dc.contributor.localIdA00152-
dc.contributor.localIdA00326-
dc.contributor.localIdA01849-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA03419-
dc.relation.journalcodeJ00886-
dc.identifier.urlhttp://www.nature.com/eye/journal/v29/n6/full/eye201558a.html-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameKim, Gyuah-
dc.contributor.alternativeNameKim, Sung Soo-
dc.contributor.alternativeNameByeon, Suk Ho-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameLee, Seung Kyu-
dc.contributor.alternativeNameRim, Tyler H. T.-
dc.contributor.affiliatedAuthorKim, Sung Soo-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorKim, Gyuah-
dc.contributor.affiliatedAuthorByeon, Suk Ho-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorLee, Seung Kyu-
dc.contributor.affiliatedAuthorRim, Tyler Hyungtaek-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number6-
dc.citation.startPage732-
dc.citation.endPage741-
dc.identifier.bibliographicCitationEye, Vol.29(6) : 732-741, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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