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The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis

 Eun Hye Kim  ;  Huapyong Kang  ;  Chan Hyuk Park  ;  Hee Seung Choi  ;  Da Hyun Jung  ;  Hyunsoo Chung  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
 Digestive and Liver Disease, Vol.47(8) : 663-668, 2015 
Journal Title
 Digestive and Liver Disease 
Issue Date
BACKGROUND: Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated. AIM: To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis. METHODS: Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system. RESULTS: Ninety-five patients were enrolled in the study. The mean age was 57.7±12.1 years, and 44.2% of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2±1.7 vs. 5.2±2.1, P=0.040; corpus, 3.3±1.9 vs. 5.4±1.9, P<0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P=0.030; corpus, P<0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2% and 60.3%, respectively. CONCLUSION: The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강화평(Kang, Huapyong) ; 김은혜(Kim, Eun Hye) ; 박준철(Park, Jun Chul) ; 신성관(Shin, Sung Kwan) ; 이상길(Lee, Sang Kil) ; 이용찬(Lee, Yong Chan) ; 정다현(Jung, Da Hyun) ; 최희승(Choi, Heeseung)
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