Cited 7 times in
Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진아 | - |
dc.contributor.author | 신나영 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 이종은 | - |
dc.contributor.author | 이혜연 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2016-02-04T11:46:36Z | - |
dc.date.available | 2016-02-04T11:46:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141177 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. RESULTS: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). CONCLUSION: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 791~797 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blood-Brain Barrier/pathology | - |
dc.subject.MESH | Capillary Permeability | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Evans Blue/analysis | - |
dc.subject.MESH | Ischemic Attack, Transient/diagnosis* | - |
dc.subject.MESH | Magnetic Resonance Imaging/instrumentation | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stroke/diagnosis | - |
dc.title | Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Hyun Seok Choi | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Na Young Shin | - |
dc.contributor.googleauthor | Jinna Kim | - |
dc.contributor.googleauthor | Jae Hyung Kim | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Hye Yeon Lee | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Seung Koo Lee | - |
dc.identifier.doi | 10.3348/kjr.2015.16.4.791 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02089 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A03313 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A02234 | - |
dc.contributor.localId | A01022 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 26175578 | - |
dc.subject.keyword | Animal models | - |
dc.subject.keyword | Blood-brain barrier | - |
dc.subject.keyword | Brain ischemia | - |
dc.subject.keyword | Dynamic contrast-enhanced MRI | - |
dc.subject.keyword | Kinetic modeling | - |
dc.contributor.alternativeName | Kim, Jinna | - |
dc.contributor.alternativeName | Shin, Na Young | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.alternativeName | Lee, Hye Yeon | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Shin, Na Young | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Lee, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Jinna | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 791 | - |
dc.citation.endPage | 797 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.16(4) : 791-797, 2015 | - |
dc.identifier.rimsid | 29345 | - |
dc.type.rims | ART | - |
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