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Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization

Authors
 Beom Kyung Kim  ;  Kyung Ah Kim  ;  Myeong-Jin Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Seung Up Kim  ;  Mi-Suk Park 
Citation
 Digestive and Liver Disease, Vol.47(8) : 682-688, 2015 
Journal Title
 Digestive and Liver Disease 
ISSN
 1590-8658 
Issue Date
2015
Abstract
BACKGROUND: Data comparing EASL and mRECIST criteria for response evaluation in treatment of hepatocellular carcinoma are rare. We evaluated inter-observer variability by these two response evaluation criteria in treatment-naïve patients undergoing chemoembolization. METHODS: For 133 patients undergoing chemoembolization, two radiologists independently measured sum of bi-dimensional and uni-dimensional diameters at baseline using both EASL criteria and mRECIST, and their changes on first follow-up for up to 5 target lesions. RESULTS: Concordance correlation coefficients for sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were 0.992 and 0.988, respectively. However, those for their changes on follow-up were 0.865 and 0.877, respectively. Similarly, mean differences in sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were small; -0.455 and 0.079 cm, respectively. However, mean differences in changes (%) in sum of bi-dimensional and uni-dimensional diameters on first follow-up between observers increased by -9.715% and -9.320%, respectively. Regarding tumour numbers, kappa-value between observers was 0.942. For treatment response (complete or partial response, stable disease and progression), kappa-value was 0.941 by both criteria. When only up to two target lesions were assessed, kappa-value was 1.000 by both criteria. CONCLUSIONS: Inter-observer agreements using both response evaluation criteria were excellent, especially when up to two targets were assessed.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141174
DOI
10.1016/j.dld.2015.04.004
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김명진(Kim, Myeong Jin) ; 김범경(Kim, Beom Kyung) ; 김승업(Kim, Seung Up) ; 박미숙(Park, Mi-Suk) ; 박준용(Park, Jun Yong) ; 안상훈(Ahn, Sang Hoon) ; 한광협(Han, Kwang Hyup)
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Full Text
http://www.sciencedirect.com/science/article/pii/S1590865815002777
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