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Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

Authors
 Hyun Gi Kim  ;  Hyun Joo Shin  ;  Yoon Hee Kim  ;  Myung Hyun Sohn  ;  Chuhl Joo Lyu  ;  Myung-Joon Kim  ;  Kyung Won Kim  ;  Mi-Jung Lee 
Citation
 European Radiology, Vol.25(10) : 2931-2936, 2015 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2015
Abstract
OBJECTIVE: To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). METHODS: This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. RESULTS: The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9% and 1.4 ± 1.9%, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P < .001) and in the correction of repetition (γ = -0.837, P = .010). CONCLUSIONS: We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. KEY POINTS: • Simple and individualized threshold attenuation setting for air trapping quantification is possible. • Individualized threshold attenuation setting is insusceptible to CT imaging protocols or respiratory phase control. • CT air trapping quantification correlates with PFT of pulmonary obstruction.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141160
DOI
10.1007/s00330-015-3700-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ; 김명준(Kim, Myung Joon) ; 김윤희(Kim, Yoon Hee) ; 김현지(Kim, Hyun Gi) ; 손명현(Sohn, Myung Hyun) ; 신현주(Shin, Hyun Joo) ; 유철주(Lyu, Chuhl Joo) ; 이미정(Lee, Mi Jung)
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Full Text
http://link.springer.com/article/10.1007%2Fs00330-015-3700-9
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