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A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis.

 Jong-Min Lee  ;  Kyoung-Won Cho  ;  Eun-Jung Kim  ;  Qinghuang Tang  ;  Kye-Seong Kim  ;  Cheryll Tickle  ;  Han-Sung Jung 
 ONCOTARGET , Vol.6(26) : 22048-22059, 2015 
Journal Title
Issue Date
mammary gland development ; breast cancer ; miR-137 ; tumour suppressor ; tachykinin-1
MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland. MiR-137 was expressed prominently in the developing mammary gland. When the miR-137 was over-expressed in the embryo, the mammary epithelium became thickened. Moreover, genes associated with mammary gland formation such as Tbx3 and Lef1 were not expressed. This suggests that miR-137 induces gland formation and invasion. When miR-137 was over-expressed in MDA-MB-231 cells, their ability to form tumours in adult mice was significantly reduced. These data support miR-137 decides epithelial cell behavior in the human breast cancer. It also suggests that miR-137 is a potential therapeutic target for amelioration of breast cancer progression.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Kyoung Won(조경원)
Tang, Qinghuang(탕칭황)
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