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Disease duration and Medsger's severity score are associated with significant liver fibrosis in patients with systemic sclerosis

 S. Lee  ;  B. Kim  ;  S. Kim  ;  K. Han  ;  Y. Park  ;  J. Song  ;  S. Ahn  ;  D. Kim  ;  J. Park 
 Clinical and Experimental Rheumatology, Vol.33(4 Suppl. 91), 2015 
Journal Title
 Clinical and Experimental Rheumatology 
Issue Date
OBJECTIVES: We investigated the prevalence and predictors of significant liver fibrosis in patients with systemic sclerosis (SSc) who had no evidences of liver diseases due to viral infection, drug, and heavy alcohol consumption. METHODS: A total of 44 SSc patients were recruited. In addition to the clinical and laboratory data, the 2013 College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria score, modified Rodnan skin score (mRSS), and Medsger's severity score (MSS) were analysed. Liver stiffness (LS) was measured using transient elastography to assess the degree of liver fibrosis and 7.4 kPa was adopted as the cut-off value for significant liver fibrosis. RESULTS: The median age of patients (38 women) was 54 years and the median disease duration was 41.0 months. The median LS value was 4.6 kPa. The median mRSS and MSS were 7.0 and 5.0, respectively. Six (13.6%) patients had significant liver fibrosis. Disease duration (standardised β=0.375, p=0.018) and MSS (standardised β=0.398, p=0.047) significantly correlated with LS values. In multivariate analysis, disease duration≥63 months (odds ratio (OR) 19.166, 95% confidence interval 1.090, 336.962, p=0.043) and MSS≥7 (OR 19.796, 95% confidence interval 1.439, 272.252, p=0.026) independently predicted the presence of significant liver fibrosis. CONCLUSIONS: The prevalence of significant liver fibrosis was relatively high (13.6%) and its independent predictors were disease duration and MSS.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김범경(Kim, Beom Kyung) ; 김승업(Kim, Seung Up) ; 박용범(Park, Yong Beom) ; 박준용(Park, Jun Yong) ; 송정식(Song, Jung Sik) ; 안상훈(Ahn, Sang Hoon) ; 이상원(Lee, Sang Won) ; 이수곤(Lee, Soo Kon) ; 한광협(Han, Kwang Hyup)
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