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Disease duration and Medsger's severity score are associated with significant liver fibrosis in patients with systemic sclerosis

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dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박용범-
dc.contributor.author박준용-
dc.contributor.author송정식-
dc.contributor.author안상훈-
dc.contributor.author이상원-
dc.contributor.author이수곤-
dc.contributor.author한광협-
dc.date.accessioned2016-02-04T11:43:32Z-
dc.date.available2016-02-04T11:43:32Z-
dc.date.issued2015-
dc.identifier.issn0392-856X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141060-
dc.description.abstractOBJECTIVES: We investigated the prevalence and predictors of significant liver fibrosis in patients with systemic sclerosis (SSc) who had no evidences of liver diseases due to viral infection, drug, and heavy alcohol consumption. METHODS: A total of 44 SSc patients were recruited. In addition to the clinical and laboratory data, the 2013 College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria score, modified Rodnan skin score (mRSS), and Medsger's severity score (MSS) were analysed. Liver stiffness (LS) was measured using transient elastography to assess the degree of liver fibrosis and 7.4 kPa was adopted as the cut-off value for significant liver fibrosis. RESULTS: The median age of patients (38 women) was 54 years and the median disease duration was 41.0 months. The median LS value was 4.6 kPa. The median mRSS and MSS were 7.0 and 5.0, respectively. Six (13.6%) patients had significant liver fibrosis. Disease duration (standardised β=0.375, p=0.018) and MSS (standardised β=0.398, p=0.047) significantly correlated with LS values. In multivariate analysis, disease duration≥63 months (odds ratio (OR) 19.166, 95% confidence interval 1.090, 336.962, p=0.043) and MSS≥7 (OR 19.796, 95% confidence interval 1.439, 272.252, p=0.026) independently predicted the presence of significant liver fibrosis. CONCLUSIONS: The prevalence of significant liver fibrosis was relatively high (13.6%) and its independent predictors were disease duration and MSS.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHFemale-
dc.subject.MESHHealth Status-
dc.subject.MESHHealth Status Indicators-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/diagnosis-
dc.subject.MESHLiver Cirrhosis/epidemiology*-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrevalence-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHScleroderma, Systemic/diagnosis-
dc.subject.MESHScleroderma, Systemic/epidemiology*-
dc.subject.MESHSeverity of Illness Index-
dc.titleDisease duration and Medsger's severity score are associated with significant liver fibrosis in patients with systemic sclerosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorS. Lee-
dc.contributor.googleauthorB. Kim-
dc.contributor.googleauthorS. Kim-
dc.contributor.googleauthorK. Han-
dc.contributor.googleauthorY. Park-
dc.contributor.googleauthorJ. Song-
dc.contributor.googleauthorS. Ahn-
dc.contributor.googleauthorD. Kim-
dc.contributor.googleauthorJ. Park-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01579-
dc.contributor.localIdA01675-
dc.contributor.localIdA02057-
dc.contributor.localIdA02226-
dc.contributor.localIdA02889-
dc.contributor.localIdA04268-
dc.contributor.localIdA02824-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00555-
dc.identifier.eissn1593-098X-
dc.identifier.pmid26243041-
dc.identifier.urlhttp://www.clinexprheumatol.org/abstract.asp?a=9398-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number4 Suppl. 91-
dc.citation.startPageS68-
dc.citation.endPageS74-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.33(4 Suppl. 91) : S68-S74, 2015-
dc.identifier.rimsid30487-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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