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Role of region-distinctive expression of Rac1 in regulating fibronectin arrangement during palatal shelf elevation

Authors
 Qinghuang Tang ; Liwen Li ; Han-Sung Jung ; Jong-Min Lee ; Chengri Jin 
Citation
 Cell and Tissue Research, Vol.361(3) : 857~868, 2015 
Journal Title
 Cell and Tissue Research 
ISSN
 0302-766X 
Issue Date
2015
Abstract
Palatal shelf elevation is a crucial process in palate development, with the contribution of various factors. Disturbances in any factor during this process result in cleft palate. Prior to palatal shelf elevation starting from embryonic day 12.5, the Rac1 expression level in the bend region of the mid-palatal shelf progressively increases and the cell densities in the bend and groove regions gradually become higher than those in the middle region. The comparative decrease of cell density in the middle region is correlated with a gradual alteration of the arrangement of fibronectin (FN) fibers, whereas the bend and groove regions with higher cell densities maintain ring-like FN arrangements. Rac1 overexpression alters the fibrillar FN arrangement in the middle region to the ring-like arrangement by increasing cell density. This alteration is sufficient to induce the failure of palatal shelf elevation, ultimately leading to cleft palate. Furthermore, the inhibition of FN delays palatal shelf elevation. Thus, the spatiotemporal expression of Rac1 plays an impressive role in palatal shelf elevation by regulating FN arrangement within the palatal shelf.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141007
DOI
10.1007/s00441-015-2169-9
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute of Craniofacial Deformity
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00441-015-2169-9
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