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Role of region-distinctive expression of Rac1 in regulating fibronectin arrangement during palatal shelf elevation

 Qinghuang Tang  ;  Liwen Li  ;  Chengri Jin  ;  Jong-Min Lee  ;  Han-Sung Jung 
 Cell and Tissue Research, Vol.361(3) : 857-868, 2015 
Journal Title
 Cell and Tissue Research 
Issue Date
Actin-Related Protein 3/metabolism ; Animals ; Cell Differentiation/physiology* ; Cleft Palate/embryology* ; Fibronectins/metabolism* ; Immunohistochemistry/methods ; Mice ; Neuropeptides/metabolism* ; Palate/embryology* ; rac1 GTP-Binding Protein/metabolism*
Rac1 ; Fibronectin ; Palatal shelf ; Elevation ; Cleft palate ; Mouse
Palatal shelf elevation is a crucial process in palate development, with the contribution of various factors. Disturbances in any factor during this process result in cleft palate. Prior to palatal shelf elevation starting from embryonic day 12.5, the Rac1 expression level in the bend region of the mid-palatal shelf progressively increases and the cell densities in the bend and groove regions gradually become higher than those in the middle region. The comparative decrease of cell density in the middle region is correlated with a gradual alteration of the arrangement of fibronectin (FN) fibers, whereas the bend and groove regions with higher cell densities maintain ring-like FN arrangements. Rac1 overexpression alters the fibrillar FN arrangement in the middle region to the ring-like arrangement by increasing cell density. This alteration is sufficient to induce the failure of palatal shelf elevation, ultimately leading to cleft palate. Furthermore, the inhibition of FN delays palatal shelf elevation. Thus, the spatiotemporal expression of Rac1 plays an impressive role in palatal shelf elevation by regulating FN arrangement within the palatal shelf.
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5. Research Institutes (연구소) > Institute of Craniofacial Deformity (두개안면기형연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jin, Chengri(김성일)
Li, Liwen(이여문)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Tang, Qinghuang(탕칭황)
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