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Synthesis of Stable Magnetic Polyaniline Nanohybrids with Pyrene as a Cross-Linker for Simultaneous Diagnosis by Magnetic Resonance Imaging and Photothermal Therapy

Authors
 Taeksu Lee  ;  Doyeon Bang  ;  Yeonji Park  ;  Young Wook Chang  ;  Byunghoon Kang  ;  Jinyoung Kim  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 European Journal of Inorganic Chemistry, Vol.2015(22) : 3740-3747, 2015 
Journal Title
 European Journal of Inorganic Chemistry 
ISSN
 1434-1948 
Issue Date
2015
Abstract
We have developed pyrene-modified magnetic polyaniline nanoparticles (MPANs), a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and polyaniline (PANI) with pyrene as a cross-linker, for diagnosis by simultaneous magnetic resonance (MR) imaging and photothermal therapy. In general, the strong affinity between PANI molecules, owing to interchain hydrogen bonding and the π–π interactions mediated by their aromatic composition, hinders the successful synthesis of complexes of PANI with inorganic materials. To overcome this obstacle, we used pyrene as a cross-linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene through a hydrophobic interaction and then formed a complex with PANI. The pyrene-induced π–π interactions between the pyrene molecules on the MNPs and PANI reduced the affinity between the PANI molecules, and the strong affinity between the PANI molecules and MNPs rendered stable nanocomplexes of MPANs. Finally, Cetuximab-conjugated MPANs were fully tested for simultaneous diagnosis by magnetic resonance imaging (MRI) from superparamagnetic MnFe2O4 and photothermal ablation therapy from the near-infrared absorbing characteristics of PANI in epidermal growth factor receptor (EGFR) overexpressed cancer cells (A-431 cells) in vitro.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140999
DOI
10.1002/ejic.201500283
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck) ; 허용민(Huh, Yong Min)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ejic.201500283/abstract
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