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Circadian Oscillation of Sulfiredoxin in the Mitochondria

Authors
 In Sup Kil  ;  Keun Woo Ryu  ;  Se Kyoung Lee  ;  Jeong Yeon Kim  ;  Sei Yoon Chu  ;  Ju Hee Kim  ;  Sunjoo Park  ;  Sue Goo Rhee 
Citation
 Molecular Cell, Vol.59(4) : 651-663, 2015 
Journal Title
 Molecular Cell 
ISSN
 1097-2765 
Issue Date
2015
Abstract
Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur. Active PrxIII-SH undergoes reversible inactivation via hyperoxidation to PrxIII-SO2, which is then reduced by sulfiredoxin. We now show that the amounts of PrxIII-SO2 and sulfiredoxin undergo antiphasic circadian oscillation in the mitochondria of specific tissues of mice maintained under normal conditions. Cytosolic sulfiredoxin was found to be imported into the mitochondria via a mechanism that requires formation of a disulfide-linked complex with heat shock protein 90, which is promoted by H2O2 released from mitochondria. The imported sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state. The coordinated import and degradation of sulfiredoxin provide the basis for sulfiredoxin oscillation and consequent PrxIII-SO2 oscillation in mitochondria and likely result in an oscillatory H2O2 release.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140859
DOI
10.1016/j.molcel.2015.06.031
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
길인섭(Kil, In Sup)
이서구(Rhee, Sue Goo)
이세경(Lee, Se Kyoung)
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