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Circadian Oscillation of Sulfiredoxin in the Mitochondria

Authors
 In Sup Kil  ;  Keun Woo Ryu  ;  Se Kyoung Lee  ;  Jeong Yeon Kim  ;  Sei Yoon Chu  ;  Ju Hee Kim  ;  Sunjoo Park  ;  Sue Goo Rhee 
Citation
 MOLECULAR CELL, Vol.59(4) : 651-663, 2015 
Journal Title
 MOLECULAR CELL 
ISSN
 1097-2765 
Issue Date
2015
MeSH
Animals ; Circadian Rhythm* ; HeLa Cells ; Heat-Shock Proteins/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/enzymology* ; Organ Specificity ; Oxidation-Reduction ; Oxidoreductases Acting on Sulfur Group Donors/metabolism* ; Peroxiredoxin III/metabolism ; Protease La/metabolism ; Protein Transport ; Proteolysis ; Sulfur Dioxide/metabolism ; Tacrolimus Binding Proteins/metabolism
Abstract
Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur. Active PrxIII-SH undergoes reversible inactivation via hyperoxidation to PrxIII-SO2, which is then reduced by sulfiredoxin. We now show that the amounts of PrxIII-SO2 and sulfiredoxin undergo antiphasic circadian oscillation in the mitochondria of specific tissues of mice maintained under normal conditions. Cytosolic sulfiredoxin was found to be imported into the mitochondria via a mechanism that requires formation of a disulfide-linked complex with heat shock protein 90, which is promoted by H2O2 released from mitochondria. The imported sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state. The coordinated import and degradation of sulfiredoxin provide the basis for sulfiredoxin oscillation and consequent PrxIII-SO2 oscillation in mitochondria and likely result in an oscillatory H2O2 release.
DOI
10.1016/j.molcel.2015.06.031
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kil, In Sup(길인섭)
Rhee, Sue Goo(이서구)
Lee, Se Kyoung(이세경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140859
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