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Circadian Oscillation of Sulfiredoxin in the Mitochondria

DC FieldValueLanguage
dc.contributor.author길인섭-
dc.contributor.author이서구-
dc.contributor.author이세경-
dc.date.accessioned2016-02-04T11:38:06Z-
dc.date.available2016-02-04T11:38:06Z-
dc.date.issued2015-
dc.identifier.issn1097-2765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140859-
dc.description.abstractHydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur. Active PrxIII-SH undergoes reversible inactivation via hyperoxidation to PrxIII-SO2, which is then reduced by sulfiredoxin. We now show that the amounts of PrxIII-SO2 and sulfiredoxin undergo antiphasic circadian oscillation in the mitochondria of specific tissues of mice maintained under normal conditions. Cytosolic sulfiredoxin was found to be imported into the mitochondria via a mechanism that requires formation of a disulfide-linked complex with heat shock protein 90, which is promoted by H2O2 released from mitochondria. The imported sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state. The coordinated import and degradation of sulfiredoxin provide the basis for sulfiredoxin oscillation and consequent PrxIII-SO2 oscillation in mitochondria and likely result in an oscillatory H2O2 release.-
dc.description.statementOfResponsibilityopen-
dc.format.extent651~663-
dc.relation.isPartOfMOLECULAR CELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCircadian Rhythm*-
dc.subject.MESHHeLa Cells-
dc.subject.MESHHeat-Shock Proteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHHydrogen Peroxide/metabolism-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMitochondria/enzymology*-
dc.subject.MESHOrgan Specificity-
dc.subject.MESHOxidation-Reduction-
dc.subject.MESHOxidoreductases Acting on Sulfur Group Donors/metabolism*-
dc.subject.MESHPeroxiredoxin III/metabolism-
dc.subject.MESHProtease La/metabolism-
dc.subject.MESHProtein Transport-
dc.subject.MESHProteolysis-
dc.subject.MESHSulfur Dioxide/metabolism-
dc.subject.MESHTacrolimus Binding Proteins/metabolism-
dc.titleCircadian Oscillation of Sulfiredoxin in the Mitochondria-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorIn Sup Kil-
dc.contributor.googleauthorKeun Woo Ryu-
dc.contributor.googleauthorSe Kyoung Lee-
dc.contributor.googleauthorJeong Yeon Kim-
dc.contributor.googleauthorSei Yoon Chu-
dc.contributor.googleauthorJu Hee Kim-
dc.contributor.googleauthorSunjoo Park-
dc.contributor.googleauthorSue Goo Rhee-
dc.identifier.doi10.1016/j.molcel.2015.06.031-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00281-
dc.contributor.localIdA02847-
dc.contributor.localIdA02878-
dc.relation.journalcodeJ02256-
dc.identifier.eissn1097-4164-
dc.identifier.pmid26236015-
dc.contributor.alternativeNameKil, In Sup-
dc.contributor.alternativeNameRhee, Sue Goo-
dc.contributor.alternativeNameLee, Se Kyoung-
dc.contributor.affiliatedAuthorKil, In Sup-
dc.contributor.affiliatedAuthorRhee, Sue Goo-
dc.contributor.affiliatedAuthorLee, Se Kyoung-
dc.rights.accessRightsnot available-
dc.citation.volume59-
dc.citation.number4-
dc.citation.startPage651-
dc.citation.endPage663-
dc.identifier.bibliographicCitationMOLECULAR CELL, Vol.59(4) : 651-663, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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