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Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension

 Hyun Jin Min  ;  Yang-Je Cho  ;  Chang-Hoon Kim  ;  Da Hee Kim  ;  Ha Yan Kim  ;  Ji In Choi  ;  Jeung-Gweon Lee  ;  Sungha Park  ;  Hyung-Ju Cho 
 YONSEI MEDICAL JOURNAL, Vol.56(5) : 1258-1265, 2015 
Journal Title
Issue Date
Adult ; Aged ; Body Mass Index ; Female ; Humans ; Hypertension/complications ; Hypertension/epidemiology* ; Male ; Middle Aged ; Polysomnography ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology* ; Waist Circumference
Resistant hypertension ; body mass index ; obesity ; polysomnography ; sleep apnea
PURPOSE: Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.
MATERIALS AND METHODS: Hypertensive patients (n=475) who underwent portable polysomnography were enrolled. The patients were categorized into controlled (n=410) and resistant HTN (n=65) groups. The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.
RESULTS: Out of 475 patients, 359 (75.6%) were diagnosed with OSA. The prevalence of OSA in resistant HTN was 87.7%, which was significantly higher than that in controlled HTN (73.7%). Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA. However, stepwise multivariate analyses revealed that resistant HTN was not an independent risk factor of OSA.
CONCLUSION: The higher prevalence and severity of OSA in resistant HTN may be due to the association of risk factors that are common to both conditions.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Kim, Ha Yan(김하얀)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Jeung Gweon(이정권)
Cho, Yang Je(조양제)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
Choi, Ji In(최지인)
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