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Relationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV-V

Authors
 Ah Young Leem  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Ae Kang  ;  Young Sam Kim  ;  Moo Suk Park  ;  Song Yee Kim  ;  Eun Young Kim  ;  Kyung Soo Chung  ;  Ji Ye Jung 
Citation
 International Journal of Chronic Obstructive Pulmonary Disease, Vol.10 : 1559-1570, 2015 
Journal Title
 International Journal of Chronic Obstructive Pulmonary Disease 
ISSN
 1178-2005 
Issue Date
2015
Abstract
BACKGROUND: Heavy metal exposure may contribute to inflammation in the lungs via increased oxidative stress, resulting in tissue destruction and obstructive lung function (OLF). In this study, we evaluated the relationship between lead and cadmium levels in blood, and lung function in the Korean population. METHODS: Pooled cross-sectional data from 5,972 subjects who participated in the Korean National Health and Nutrition Examination Survey 2008-2012 were used for this study. OLF was defined as forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) <0.7. Graphite-furnace atomic absorption spectrometry was used to measure levels of lead and cadmium in blood. RESULTS: Adjusted means for age, sex, body mass index, and smoking status in blood lead and cadmium levels were increased with age and were higher in men and current smokers. The FEV1/FVC ratio was lower in the highest quartile group of lead (78.4% vs 79.0%; P=0.025) and cadmium (78.3% vs 79.2%; P<0.001) concentrations, compared with those in the lowest quartile groups. Multiple linear regression demonstrated an inverse relationship between the FEV1/FVC ratio and concentrations of lead (estimated -0.002; P=0.007) and cadmium (estimated -0.005; P=0.001). Of the 5,972 subjects, 674 (11.3%) were classified into the OLF group. Among current smokers, the risk of OLF was higher in subjects in the highest quartile group of cadmium concentration than in those in the lowest quartile group (odds ratio 1.94; 95% confidence interval 1.06-3.57). CONCLUSION: We demonstrated a significant association between the FEV1/FVC ratio and blood concentrations of lead and cadmium in the Korean population. The risk for OLF was elevated with increasing concentrations of cadmium among current smokers.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140824
Files in This Item:
T201502944.pdf Download
DOI
10.2147/COPD.S86182
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae)
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee)
김영삼(Kim, Young Sam)
김은영(Kim, Eun Young)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
임아영(Leem, Ah Young)
장준(Chang, Joon)
정경수(Jung, Kyung Soo)
정지예(Jung, Ji Ye) ORCID logo https://orcid.org/0000-0003-1589-4142
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