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Relationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV-V

DC FieldValueLanguage
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author임아영-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.date.accessioned2016-02-04T11:37:09Z-
dc.date.available2016-02-04T11:37:09Z-
dc.date.issued2015-
dc.identifier.issn1176-9106-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140824-
dc.description.abstractBACKGROUND: Heavy metal exposure may contribute to inflammation in the lungs via increased oxidative stress, resulting in tissue destruction and obstructive lung function (OLF). In this study, we evaluated the relationship between lead and cadmium levels in blood, and lung function in the Korean population. METHODS: Pooled cross-sectional data from 5,972 subjects who participated in the Korean National Health and Nutrition Examination Survey 2008-2012 were used for this study. OLF was defined as forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) <0.7. Graphite-furnace atomic absorption spectrometry was used to measure levels of lead and cadmium in blood. RESULTS: Adjusted means for age, sex, body mass index, and smoking status in blood lead and cadmium levels were increased with age and were higher in men and current smokers. The FEV1/FVC ratio was lower in the highest quartile group of lead (78.4% vs 79.0%; P=0.025) and cadmium (78.3% vs 79.2%; P<0.001) concentrations, compared with those in the lowest quartile groups. Multiple linear regression demonstrated an inverse relationship between the FEV1/FVC ratio and concentrations of lead (estimated -0.002; P=0.007) and cadmium (estimated -0.005; P=0.001). Of the 5,972 subjects, 674 (11.3%) were classified into the OLF group. Among current smokers, the risk of OLF was higher in subjects in the highest quartile group of cadmium concentration than in those in the lowest quartile group (odds ratio 1.94; 95% confidence interval 1.06-3.57). CONCLUSION: We demonstrated a significant association between the FEV1/FVC ratio and blood concentrations of lead and cadmium in the Korean population. The risk for OLF was elevated with increasing concentrations of cadmium among current smokers.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1559~1570-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCadmium/blood*-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHLead/blood*-
dc.subject.MESHLinear Models-
dc.subject.MESHLogistic Models-
dc.subject.MESHLung/physiopathology*-
dc.subject.MESHLung Diseases, Obstructive/blood*-
dc.subject.MESHLung Diseases, Obstructive/diagnosis-
dc.subject.MESHLung Diseases, Obstructive/epidemiology-
dc.subject.MESHLung Diseases, Obstructive/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking/adverse effects-
dc.subject.MESHSmoking/blood-
dc.subject.MESHSpectrophotometry, Atomic-
dc.subject.MESHSpirometry-
dc.subject.MESHUp-Regulation-
dc.subject.MESHVital Capacity-
dc.titleRelationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV-V-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorJi Ye Jung-
dc.identifier.doi10.2147/COPD.S86182-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA03382-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.contributor.localIdA00811-
dc.relation.journalcodeJ01095-
dc.identifier.eissn1178-2005-
dc.identifier.pmid26345298-
dc.subject.keywordcadmium-
dc.subject.keywordlead-
dc.subject.keywordobstructive lung disease-
dc.subject.keywordpulmonary function-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Eun Young-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameLeem, Ah Young-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorLeem, Ah Young-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.contributor.affiliatedAuthorKim, Eun Young-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.startPage1559-
dc.citation.endPage1570-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol.10 : 1559-1570, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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