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Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology

Authors
 Vivian Youngjean Park  ;  Eun-Kyung Kim  ;  Jin Young Kwak  ;  Jung Hyun Yoon  ;  Hee Jung Moon 
Citation
 European Radiology, Vol.25(9) : 2601-2607, 2015 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2015
Abstract
PURPOSE: To evaluate the malignancy risk and characteristics of thyroid nodules with two "Atypia of Undetermined Significance" or "Follicular Lesion of Undetermined Significance" (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. METHODS: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. RESULTS: Thirty-one percent (18/58) of nodules with two AUS/FLUS results and 58.1% (18/31) of confirmed nodules were malignant. Age, gender, nodule size, ultrasound features and TIRADS categories did not differ between benign and malignant nodules or between malignancies with one and two AUS/FLUS results. Malignancies with two AUS/FLUS results had a higher proportion of a follicular variant of papillary thyroid carcinoma (PTC) (46.7% vs. 13.6%, P = 0.009). CONCLUSIONS: Thyroid nodules with two AUS/FLUS results had a high malignancy risk of at least 31.0% and a higher proportion of a follicular variant of PTC. Surgery should be considered regardless of ultrasound features. KEY POINTS: • Thyroid nodules with two consecutive AUS/FLUS results had a high malignancy risk. • Ultrasound features are less useful in nodules with two AUS/FLUS results. • The follicular variant of PTC is more frequent in malignancies with two AUS/FLUS results.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140817
DOI
10.1007/s00330-015-3668-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
곽진영(Kwak, Jin Young) ; 김은경(Kim, Eun-Kyung) ; 문희정(Moon, Hee Jung) ; 박영진(Park, Vivian Youngjean) ; 윤정현(Yoon, Jung Hyun)
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Full Text
http://link.springer.com/article/10.1007%2Fs00330-015-3668-5
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