141 92

Cited 10 times in

The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Authors
 Kyung Ho Pak  ;  Ara Jo  ;  Hye Ji Choi  ;  Younghee Choi  ;  Hyunki Kim  ;  Jae-Ho Cheong 
Citation
 BMC Cancer, Vol.15 : 498-498, 2015 
Journal Title
 BMC Cancer 
ISSN
 1471-2407 
Issue Date
2015
Abstract
BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer. METHODS: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas. RESULTS: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05). CONCLUSIONS: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140801
DOI
10.1186/s12885-015-1501-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김현기(Kim, Hyunki)
정재호(Cheong, Jae Ho)
조아라(Jo, Ara)
최혜지(Choi, Hye Ji)
사서에게 알리기
  feedback
Files in This Item:
T201502923.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse