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The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

 Kyung Ho Pak  ;  Ara Jo  ;  Hye Ji Choi  ;  Younghee Choi  ;  Hyunki Kim  ;  Jae-Ho Cheong 
 BMC CANCER, Vol.15 : 498, 2015 
Journal Title
Issue Date
Disease Progression ; Disease-Free Survival ; Female ; Humans ; Lymphangiogenesis* ; Male ; Middle Aged ; Neovascularization, Pathologic ; Prognosis ; Prospective Studies ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/mortality* ; Stomach Neoplasms/pathology*
Lymphangiogenesis ; Lymphovascular density (LVD) ; Gastric cancer
BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer. METHODS: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas. RESULTS: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05). CONCLUSIONS: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Jo, Ara(조아라)
Choi, Hye Ji(최혜지)
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