Cited 29 times in
The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 조아라 | - |
dc.contributor.author | 최혜지 | - |
dc.date.accessioned | 2016-02-04T11:36:31Z | - |
dc.date.available | 2016-02-04T11:36:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140801 | - |
dc.description.abstract | BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer. METHODS: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas. RESULTS: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05). CONCLUSIONS: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 498 | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphangiogenesis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neovascularization, Pathologic | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Stomach Neoplasms/diagnosis | - |
dc.subject.MESH | Stomach Neoplasms/epidemiology | - |
dc.subject.MESH | Stomach Neoplasms/mortality* | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.title | The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Kyung Ho Pak | - |
dc.contributor.googleauthor | Ara Jo | - |
dc.contributor.googleauthor | Hye Ji Choi | - |
dc.contributor.googleauthor | Younghee Choi | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.1186/s12885-015-1501-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03849 | - |
dc.contributor.localId | A04218 | - |
dc.relation.journalcode | J00351 | - |
dc.identifier.eissn | 1471-2407 | - |
dc.identifier.pmid | 26141595 | - |
dc.subject.keyword | Lymphangiogenesis | - |
dc.subject.keyword | Lymphovascular density (LVD) | - |
dc.subject.keyword | Gastric cancer | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Jo, Ara | - |
dc.contributor.alternativeName | Choi, Hye Ji | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Jo, Ara | - |
dc.contributor.affiliatedAuthor | Choi, Hye Ji | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 498 | - |
dc.identifier.bibliographicCitation | BMC CANCER, Vol.15 : 498, 2015 | - |
dc.identifier.rimsid | 30320 | - |
dc.type.rims | ART | - |
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