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Extracellular volume fraction in dilated cardiomyopathy patients without obvious late gadolinium enhancement: comparison with healthy control subjects

Authors
 Yoo Jin Hong  ;  Chul Hwan Park  ;  Young Jin Kim  ;  Jin Hur  ;  Hye-Jeong Lee  ;  Sae Rom Hong  ;  Young Joo Suh  ;  Andreas Greiser  ;  Mun Young Paek  ;  Byoung Wook Choi  ;  Tae Hoon Kim 
Citation
 International Journal of Cardiovascular Imaging, Vol.31(Suppl 1) : 115-122, 2015 
Journal Title
 International Journal of Cardiovascular Imaging 
ISSN
 1569-5794 
Issue Date
2015
Abstract
To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 - hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 - pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140730
DOI
10.1007/s10554-015-0595-0
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김영진(Kim, Young Jin) ; 김태훈(Kim, Tae Hoon) ; 박철환(Park, Chul Hwan) ; 서영주(Suh, Young Joo) ; 이혜정(Lee, Hye Jeong) ; 최병욱(Choi, Byoung Wook) ; 허진(Hur, Jin) ; 홍새롬(Hong, Sae Rom) ; 홍유진(Hong, Yoo Jin)
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Full Text
http://link.springer.com/article/10.1007%2Fs10554-015-0595-0
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