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Extracellular volume fraction in dilated cardiomyopathy patients without obvious late gadolinium enhancement: comparison with healthy control subjects

Authors
 Yoo Jin Hong  ;  Chul Hwan Park  ;  Young Jin Kim  ;  Jin Hur  ;  Hye-Jeong Lee  ;  Sae Rom Hong  ;  Young Joo Suh  ;  Andreas Greiser  ;  Mun Young Paek  ;  Byoung Wook Choi  ;  Tae Hoon Kim 
Citation
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.31(Suppl 1) : 115-122, 2015 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 
ISSN
 1569-5794 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiomyopathy, Dilated/diagnosis* ; Cardiomyopathy, Dilated/pathology* ; Cardiomyopathy, Dilated/physiopathology ; Case-Control Studies ; Contrast Media* ; Feasibility Studies ; Female ; Fibrosis ; Heart Ventricles/pathology* ; Heart Ventricles/physiopathology ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging, Cine* ; Male ; Middle Aged ; Organometallic Compounds* ; Predictive Value of Tests ; Prospective Studies ; Stroke Volume ; Ventricular Function, Left ; Young Adult
Keywords
Cardiomyopathy ; Dilated ; Extracellular space ; Magnetic resonance imaging ; Gadolinium ; Fibrosis ; Myocardium ; T1 mapping
Abstract
To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 - hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 - pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.
Full Text
http://link.springer.com/article/10.1007%2Fs10554-015-0595-0
DOI
10.1007/s10554-015-0595-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Sae Rom(홍새롬)
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140730
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