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Initial study on in vivo conductivity mapping of breast cancer using MRI.

Authors
 Jaewook Shin  ;  Min Jung Kim  ;  Joonsung Lee  ;  Yoonho Nam  ;  Minoh Kim  ;  Narae Choi  ;  Sooyeon Kim  ;  Dong Hyun Kim 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.42(2) : 371-378, 2015 
Journal Title
 JOURNAL OF MAGNETIC RESONANCE IMAGING 
ISSN
 1053-1807 
Issue Date
2015
MeSH
Adult ; Aged ; Algorithms* ; Breast Neoplasms/pathology* ; Breast Neoplasms/physiopathology* ; Electric Conductivity ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods* ; Magnetic Resonance Imaging/methods* ; Middle Aged ; Pilot Projects ; Plethysmography, Impedance/methods* ; Reproducibility of Results ; Sensitivity and Specificity
Keywords
breast cancer ; electrical conductivity mapping ; electrical properties ; magnetic resonance ; tomography
Abstract
PURPOSE: To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. MATERIALS AND METHODS: A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2 -weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. RESULTS: By employing the coil combination, the relative error in the conductivity map was reduced from ~70% to 10%. The average conductivity values in breast cancers regions (0.89 ± 0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). CONCLUSION: This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.24803/abstract
DOI
10.1002/jmri.24803
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Soo Yeon(김수연)
Lee, Joonsung(이준성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140717
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