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Ridge regeneration of damaged extraction sockets using rhBMP-2: an experimental study in canine

Authors
 Jung-Seok Lee ; Jae-Suk Jung ; Chang-Sung Kim ; Kyoo-Sung Cho ; Byung-Soo Kim ; Gun-Il Im 
Citation
 Journal of Clinical Periodontology, Vol.42(7) : 678~687, 2015 
Journal Title
 Journal of Clinical Periodontology 
ISSN
 0303-6979 
Issue Date
2015
Abstract
OBJECTIVES: This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering. MATERIAL AND METHODS: In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and grafting with (2) deproteinized bovine bone mineral (DBBM), (3) DBBM/rhBMP-2 and (4) DBBM covered with a collagen membrane (DBBM/Membrane). Quantitative/qualitative analyses were performed radiographically/histologically after 8 weeks. RESULTS: Buccal-deficient extraction sockets healed with significant reduction in buccolingual dimension along the entire length of the socket, but all grafting techniques reduced the dimensional changes compared to the non-grafted control sites. Histologically, sites received DBBM only exhibited minimal regeneration, whereas sites grafted with DBBM/rhBMP-2 or DBBM/Membrane exhibited greater new bone formation extending the entire augmented area. CONCLUSIONS: Buccal-bone-deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rhBMP-2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140712
DOI
10.1111/jcpe.12414
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Periodontology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12414/abstract
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