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Ridge regeneration of damaged extraction sockets using rhBMP-2: an experimental study in canine

Authors
 Jung-Seok Lee  ;  Jae-Suk Jung  ;  Gun-Il Im  ;  Byung-Soo Kim  ;  Kyoo-Sung Cho  ;  Chang-Sung Kim 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.42(7) : 678-687, 2015 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2015
MeSH
Alveolar Bone Loss/drug therapy* ; Alveolar Bone Loss/surgery ; Alveolar Ridge Augmentation/methods ; Animals ; Bone Morphogenetic Protein 2/therapeutic use* ; Bone Regeneration/drug effects* ; Bone Regeneration/physiology ; Bone Substitutes/therapeutic use ; Cattle ; Collagen ; Dogs ; Humans ; Male ; Mandible/drug effects ; Mandible/pathology ; Mandible/surgery ; Membranes, Artificial ; Minerals/therapeutic use ; Osteogenesis/drug effects ; Osteogenesis/physiology ; Random Allocation ; Recombinant Proteins/therapeutic use ; Tooth Extraction/adverse effects ; Tooth Socket/drug effects* ; Tooth Socket/pathology ; Tooth Socket/surgery ; Transforming Growth Factor beta/therapeutic use* ; X-Ray Microtomography/methods
Keywords
alveolar ridge augmentation ; bone morphogenetic protein 2 ; guided bone regeneration ; ooth extraction ; ridge preservation
Abstract
OBJECTIVES: This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering. MATERIAL AND METHODS: In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and grafting with (2) deproteinized bovine bone mineral (DBBM), (3) DBBM/rhBMP-2 and (4) DBBM covered with a collagen membrane (DBBM/Membrane). Quantitative/qualitative analyses were performed radiographically/histologically after 8 weeks. RESULTS: Buccal-deficient extraction sockets healed with significant reduction in buccolingual dimension along the entire length of the socket, but all grafting techniques reduced the dimensional changes compared to the non-grafted control sites. Histologically, sites received DBBM only exhibited minimal regeneration, whereas sites grafted with DBBM/rhBMP-2 or DBBM/Membrane exhibited greater new bone formation extending the entire augmented area. CONCLUSIONS: Buccal-bone-deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rhBMP-2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12414/abstract
DOI
10.1111/jcpe.12414
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140712
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