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Cited 6 times in

RAS Mutations in AUS/FLUS Cytology: Does it Have an Additional Role in BRAFV600E Mutation-Negative Nodules?

DC FieldValueLanguage
dc.contributor.author곽진영-
dc.contributor.author권형주-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.contributor.author이혜선-
dc.date.accessioned2016-02-04T11:31:28Z-
dc.date.available2016-02-04T11:31:28Z-
dc.date.issued2015-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140618-
dc.description.abstractThe object of this study is to evaluate the additional role of RAS mutation in detecting thyroid malignancy among BRAF mutation-negative nodules diagnosed as atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology.From December 2009 to December 2011, 202 BRAF mutation-negative thyroid nodules diagnosed as AUS/FLUS cytology in 201 patients were included in this study. RAS mutation analysis was performed using residual material from ultrasonography-guided fine needle aspiration (US-FNA) cytology testing for K-RAS, N-RAS, and H-RAS codons 12/13 and 61 point mutations. The authors evaluated the association between RAS mutation status and cytopathologic characteristics.Of the 202 BRAF mutation-negative thyroid nodules with AUS/FLUS cytology, 4 were considered insufficient for mutation analysis. Of the 198 thyroid nodules, 148 (74.7%) were confirmed as benign and 50 (25.3%) as malignant. Thirty-one (15.7%) of the 198 thyroid nodules were positive for any RAS mutation, 4 positive for K-RAS 12/13, 26 for N-RAS 61, and 1 positive for H-RAS 61. Seven (22.6%) of the RAS mutation positive nodules were malignant, 1 with K-RAS 12/13, 6 with N-RAS 61. Twenty-four (77.4%) of the 31 nodules positive for K-RAS 12/13 (N = 3), N-RAS 61 (N = 20), or H-RAS 61 (N = 1) mutations were proven benign. None of the 198 thyroid nodules were positive for K-RAS 61, N-RAS 12/13, or H-RAS 12/13 mutations.N-RAS 61 mutation is the most common mutation detected among BRAF mutation-negative nodules with AUS/FLUS cytology. RAS mutation has limited value in predicting malignancy among BRAF mutation-negative thyroid nodules with AUS/FLUS cytology and further, investigation is anticipated to evaluate the true role of RAS mutation in thyroid malignancy.-
dc.description.statementOfResponsibilityopen-
dc.format.extente1084-
dc.relation.isPartOfMedicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRAS Mutations in AUS/FLUS Cytology: Does it Have an Additional Role in BRAFV600E Mutation-Negative Nodules?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorHyeong Ju Kwon-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1097/MD.0000000000001084-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03312-
dc.contributor.localIdA00182-
dc.contributor.localIdA00264-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ02214-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKwon, Hyeong Ju-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKwon, Hyeong Ju-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.rights.accessRightsfree-
dc.citation.volume94-
dc.citation.number27-
dc.citation.startPage1084-
dc.citation.endPage1084-
dc.identifier.bibliographicCitationMedicine, Vol.94(27) : 1084-1084, 2015-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)

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