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Discrimination of Tumorous Intracerebral Hemorrhage from Benign Causes Using CT Densitometry

DC Field Value Language
dc.contributor.author안성수-
dc.contributor.author이승구-
dc.contributor.author임형택-
dc.contributor.author최윤성-
dc.date.accessioned2016-02-04T11:25:51Z-
dc.date.available2016-02-04T11:25:51Z-
dc.date.issued2015-
dc.identifier.issn0195-6108-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140407-
dc.description.abstractBACKGROUND AND PURPOSE: Differentiation of tumorous intracerebral hemorrhage from benign etiology is critical in initial treatment plan and prognosis. Our aim was to investigate the diagnostic value of CT densitometry to discriminate tumorous and nontumorous causes of acute intracerebral hemorrhage. MATERIALS AND METHODS: This retrospective study included 110 patients with acute intracerebral hemorrhage classified into 5 groups: primary intracerebral hemorrhage without (group 1) or with antithrombotics (group 2) and secondary intracerebral hemorrhage with vascular malformation (group 3), brain metastases (group 4), or primary brain tumors (group 5). The 5 groups were dichotomized into tumorous (groups 4 and 5) and nontumorous intracerebral hemorrhage (groups 1-3). Histogram parameters of hematoma attenuation on nonenhanced CT were compared among the groups and between tumorous and nontumorous intracerebral hemorrhages. With receiver operating characteristic analysis, optimal cutoffs and area under the curve were calculated for discriminating tumorous and nontumorous intracerebral hemorrhages. RESULTS: Histogram analysis of acute intracerebral hemorrhage attenuation showed that group 1 had higher mean, 5th, 25th, 50th, and 75th percentile values than groups 4 and 5 and higher minimum and 5th percentile values than group 2. Group 3 had higher 5th percentile values than groups 4 and 5. After dichotomization, all histogram parameters except maximum and kurtosis were different between tumorous and nontumorous intracerebral hemorrhages, with tumors having lower cumulative histogram parameters and positive skewness. In receiver operating characteristic analysis, 5th and 25th percentile values showed the highest diagnostic performance for discriminating tumorous and nontumorous intracerebral hemorrhages, with 0.81 area under the curve, cutoffs of 34 HU and 44 HU, sensitivities of 65.6% and 70.0%, and specificities of 85.0% and 80.0%, respectively. CONCLUSIONS: CT densitometry of intracerebral hemorrhage on nonenhanced CT might be useful for discriminating tumorous and nontumorous causes of acute intracerebral hemorrhage.-
dc.description.statementOfResponsibilityopen-
dc.format.extent886~892-
dc.relation.isPartOfAMERICAN JOURNAL OF NEURORADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBrain Neoplasms/complications-
dc.subject.MESHBrain Neoplasms/diagnostic imaging*-
dc.subject.MESHCentral Nervous System Vascular Malformations/complications-
dc.subject.MESHCentral Nervous System Vascular Malformations/diagnostic imaging*-
dc.subject.MESHCerebral Hemorrhage/diagnostic imaging*-
dc.subject.MESHCerebral Hemorrhage/etiology*-
dc.subject.MESHDensitometry-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTomography, X-Ray Computed/methods*-
dc.titleDiscrimination of Tumorous Intracerebral Hemorrhage from Benign Causes Using CT Densitometry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorY.S. Choi-
dc.contributor.googleauthorT.H. Rim-
dc.contributor.googleauthorS.S. Ahn-
dc.contributor.googleauthorS.-K. Lee-
dc.identifier.doi10.3174/ajnr.A4233-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02234-
dc.contributor.localIdA02912-
dc.contributor.localIdA03419-
dc.contributor.localIdA04137-
dc.relation.journalcodeJ00095-
dc.identifier.eissn1936-959X-
dc.identifier.pmid25634719-
dc.identifier.urlhttp://www.ajnr.org/content/36/5/886.long-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameRim, Tyler H. T.-
dc.contributor.alternativeNameChoi, Yoon Seong-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorRim, Tyler Hyungtaek-
dc.contributor.affiliatedAuthorChoi, Yoon Seong-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage886-
dc.citation.endPage892-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF NEURORADIOLOGY, Vol.36(5) : 886-892, 2015-
dc.identifier.rimsid51990-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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