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Modulation of dendritic cell function by Trichomonas vaginalis-derived secretory products

 Min-Ji Song  ;  Jong-Joo Lee  ;  Young Hee Nam  ;  Tae-Gyun Kim  ;  Youn Wook Chung  ;  Mikyoung Kim  ;  Ye-Eun Choi  ;  Myeong Heon Shin  ;  Hyoung-Pyo Kim 
 BMB REPORTS, Vol.48(2) : 103-108, 2015 
Journal Title
Issue Date
Animals ; Antigens, Protozoan/immunology ; Antigens, Protozoan/metabolism ; Antigens, Protozoan/pharmacology ; Bone Marrow Cells/cytology ; Cell Differentiation ; Chromatin Immunoprecipitation ; Dendritic Cells/cytology* ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Down-Regulation/drug effects ; Endopeptidase K/metabolism ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Interleukin-10 ; Interleukin-12 ; Lipopolysaccharides/toxicity ; Mice ; Mice, Inbred C57BL ; Trichomonas vaginalis/metabolism* ; Up-Regulation/drug effects
Chromatin ; Cytokine ; Dendritic cells ; Tolerance ; Trichomonas vaginalis
Trichomoniasis caused by the parasitic protozoan Trichomonas vaginalis is the most common sexually transmitted disease in the world. Dendritic cells are antigen presenting cells that initiate immune responses by directing the activation and differentiation of naïve T cells. In this study, we analyzed the effect of Trichomonas vaginalis-derived Secretory Products on the differentiation and function of dendritic cells. Differentiation of bone marrow-derived dendritic cells in the presence of T. vaginalis-derived Secretory Products resulted in inhibition of lipopolysaccharide-induced maturation of dendritic cells, down-regulation of IL-12, and up-regulation of IL-10. The protein components of T. vaginalis-derived Secretory Products were shown to be responsible for altered function of bone marrow- derived dendritic cells. Chromatin immunoprecipitation assay demonstrated that IL-12 expression was regulated at the chromatin level in T. vaginalis-derived Secretory Productstreated dendritic cells. Our results demonstrated that T. vaginalis- derived Secretory Products modulate the maturation and cytokine production of dendritic cells leading to immune tolerance.
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Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
Nam, Young Hee(남영희)
Song, Min Ji(송민지)
Shin, Myeong Heon(신명헌) ORCID logo https://orcid.org/0000-0001-8207-6110
Lee, Jong Joo(이종주)
Chung, Youn Wook(정연욱) ORCID logo https://orcid.org/0000-0002-4382-1410
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