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Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury

Authors
 Jae Young Kim  ;  Yong Woo Lee  ;  Jae Hwan Kim  ;  Won Taek Lee  ;  Kyung Ah Park  ;  Jong Eun Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.30(7) : 943-952, 2015 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2015
MeSH
Active Transport, Cell Nucleus/drug effects ; Agmatine/therapeutic use* ; Animals ; Apoptosis/drug effects* ; Aquaporins/metabolism ; Blood-Brain Barrier/physiopathology ; Brain Edema/drug therapy* ; Brain Injuries/pathology* ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Motor Cortex/pathology* ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Rats ; Rats, Sprague-Dawley
Keywords
Agmatine ; Aquaporins ; Blood-Brain Barrier ; Brain Edema ; Mitogen-Activated Protein Kinases ; Traumatic Brain Injury
Abstract
Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after TBI. TBI was produced by cold injury to the cerebral primary motor cortex of rats. Agmatine was administered 30 min after injury and once daily until the end of the experiment. Animals were sacrificed for analysis at 1, 2, or 7 days after the injury. Various neurological analyses were performed to investigate disruption of the blood-brain barrier (BBB) and neurological dysfunction after TBI. To examine the extent of brain edema after TBI, the expression of aquaporins (AQPs), phosphorylation of mitogen-activated protein kinases (MAPKs), and nuclear translocation of nuclear factor-κB (NF-κB) were investigated. Our findings demonstrated that agmatine treatment significantly reduces brain edema after TBI by suppressing the expression of AQP1, 4, and 9. In addition, agmatine treatment significantly reduced apoptotic cell death by suppressing the phosphorylation of MAPKs and by increasing the nuclear translocation of NF-κB after TBI. These results suggest that agmatine treatment may have therapeutic potential for brain edema and neural cell death in various central nervous system diseases.
Files in This Item:
T201501855.pdf Download
DOI
10.3346/jkms.2015.30.7.943
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Park, Kyung Ah(박경아)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140325
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