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Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBα and circadian typologies

Authors
 Jee In Kang  ;  Chun Il Park  ;  Kee Namkoong  ;  Se Joo Kim 
Citation
 Chronobiology International, Vol.32(4) : 568-572, 2015 
Journal Title
 Chronobiology International 
ISSN
 0742-0528 
Issue Date
2015
Abstract
Nuclear receptor REV-ERBα, a key component of an internal timekeeping system, has been considered to be related to disrupted circadian rhythms and mood disorder. In this study, we aimed to evaluate the relationship between the genotype frequencies of single gene polymorphisms (SNPs) of the NR1D1 gene encoding REV-ERBα and circadian typologies. The classification of chronotypes and genotyping of three SNPs (rs2314339, rs2071427, rs12941497) of the NR1D1 gene were conducted in 602 healthy young adults (355 males, 247 females). A significant association was found between the genotypes of rs12941497 and three chronotype categories. These findings support the role of NR1D1 polymorphisms in the regulation of circadian rhythms.
Full Text
http://www.tandfonline.com/doi/full/10.3109/07420528.2015.1006327
DOI
10.3109/07420528.2015.1006327
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Park, Chun Il(박천일) ORCID logo https://orcid.org/0000-0003-0119-0443
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140296
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