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Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBα and circadian typologies

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author남궁기-
dc.contributor.author박천일-
dc.date.accessioned2016-02-04T11:22:50Z-
dc.date.available2016-02-04T11:22:50Z-
dc.date.issued2015-
dc.identifier.issn0742-0528-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140296-
dc.description.abstractNuclear receptor REV-ERBα, a key component of an internal timekeeping system, has been considered to be related to disrupted circadian rhythms and mood disorder. In this study, we aimed to evaluate the relationship between the genotype frequencies of single gene polymorphisms (SNPs) of the NR1D1 gene encoding REV-ERBα and circadian typologies. The classification of chronotypes and genotyping of three SNPs (rs2314339, rs2071427, rs12941497) of the NR1D1 gene were conducted in 602 healthy young adults (355 males, 247 females). A significant association was found between the genotypes of rs12941497 and three chronotype categories. These findings support the role of NR1D1 polymorphisms in the regulation of circadian rhythms.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCHRONOBIOLOGY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHCircadian Rhythm/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGene Products, rev/genetics*-
dc.subject.MESHGenotype*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMood Disorders/genetics*-
dc.subject.MESHNuclear Receptor Subfamily 1, Group D, Member 1/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide/genetics*-
dc.subject.MESHYoung Adult-
dc.titleAssociations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBα and circadian typologies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorChun Il Park-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.3109/07420528.2015.1006327-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ00531-
dc.identifier.eissn1525-6073-
dc.identifier.pmid25798852-
dc.identifier.urlhttp://www.tandfonline.com/doi/full/10.3109/07420528.2015.1006327-
dc.subject.keywordAssociation-
dc.subject.keywordNR1D1 gene-
dc.subject.keywordREV-ERBα-
dc.subject.keywordchronotype-
dc.subject.keywordcircadian rhythm-
dc.subject.keywordgenetics-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number4-
dc.citation.startPage568-
dc.citation.endPage572-
dc.identifier.bibliographicCitationCHRONOBIOLOGY INTERNATIONAL, Vol.32(4) : 568-572, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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