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Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011)

 Hye-Jung Kim  ;  Jee-Yon Lee  ;  Tae-Jong Kim  ;  Ji-Won Lee 
 Health Qual Life Outcomes, Vol.13 : 48, 2015 
Journal Title
 Health Qual Life Outcomes 
Issue Date
Adolescent ; Aged ; Aged, 80 and over ; Causality ; Child ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Mobility Limitation ; Nutrition Assessment ; Osteoarthritis, Knee/blood* ; Osteoarthritis, Knee/epidemiology* ; Osteoarthritis, Knee/prevention & control ; Osteoarthritis, Knee/psychology ; Prevalence ; Quality of Life* ; Republic of Korea/epidemiology ; Self Care ; Vitamin D/blood* ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology*
Vitamin D ; Quality of life ; EQ-VAS ; EQ-5D ; Osteoarthritis, knee
BACKGROUND: Vitamin D is important in bone health and its relationship with osteoarthritis has recently been reported. Both vitamin D deficiency and knee osteoarthritis are age dependent and are known to affect quality of life (QOL) in older populations. In this study, we aimed to determine the association between vitamin D status and health-related quality of life (HRQOL) in an older Korean population with knee osteoarthritis. METHODS: A total of 2,165 participants aged ≥50 years with radiographic knee osteoarthritis defined as Kellgren-Lawrence (KL) grade ≥2 were selected from data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V), a representative cross-sectional nationwide survey conducted in 2010-2011. They stratified into two levels by vitamin D status (deficiency <10 ng/dL and normal ≥10 ng/dL). HRQOL was measured using the EuroQOL visual analogue scale (EQ-VAS) and the five dimensions and summary index of the EuroQOL-5 dimension (EQ-5D). RESULTS: The vitamin D deficiency group was more likely to report problems with mobility, self-care, and usual activities. Vitamin D deficiency was significantly associated with poor HRQOL indicated by the lowest quartile of EQ-VAS (unadjusted odds ratio [OR] =1.832, p = 0.006) and the lowest quartile of the EQ-5D index (unadjusted OR = 1.992, p = 0.003). Theses associations of vitamin D status with EQ-VAS and EQ-5D index were maintained after adjustment for age and sex (Model 1: OR = 1.677, p = 0.022 and OR = 1.701, p = 0.021, respectively). The significant associations of vitamin D status with EQ-VAS were maintained after adjustment for other possible covariates (Model 3: OR = 1.562, p = 0.044). Also, a trend of associations between vitamin D status and EQ-5D index were shown after adjustment for other covariates (Model3: OR = 1.681, p = 0.056). CONCLUSION: This is the first study to reveal that vitamin D status is independently associated with HRQOL in an older Korean population with knee osteoarthritis. Our results suggest that the maintenance of sufficient vitamin D status may be important to prevent QOL decline in older populations with knee osteoarthritis.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jee Yon(이지연)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
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