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Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011)

DC FieldValueLanguage
dc.contributor.author이지연-
dc.contributor.author이지원-
dc.date.accessioned2016-02-04T11:22:11Z-
dc.date.available2016-02-04T11:22:11Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140272-
dc.description.abstractBACKGROUND: Vitamin D is important in bone health and its relationship with osteoarthritis has recently been reported. Both vitamin D deficiency and knee osteoarthritis are age dependent and are known to affect quality of life (QOL) in older populations. In this study, we aimed to determine the association between vitamin D status and health-related quality of life (HRQOL) in an older Korean population with knee osteoarthritis. METHODS: A total of 2,165 participants aged ≥50 years with radiographic knee osteoarthritis defined as Kellgren-Lawrence (KL) grade ≥2 were selected from data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V), a representative cross-sectional nationwide survey conducted in 2010-2011. They stratified into two levels by vitamin D status (deficiency <10 ng/dL and normal ≥10 ng/dL). HRQOL was measured using the EuroQOL visual analogue scale (EQ-VAS) and the five dimensions and summary index of the EuroQOL-5 dimension (EQ-5D). RESULTS: The vitamin D deficiency group was more likely to report problems with mobility, self-care, and usual activities. Vitamin D deficiency was significantly associated with poor HRQOL indicated by the lowest quartile of EQ-VAS (unadjusted odds ratio [OR] =1.832, p = 0.006) and the lowest quartile of the EQ-5D index (unadjusted OR = 1.992, p = 0.003). Theses associations of vitamin D status with EQ-VAS and EQ-5D index were maintained after adjustment for age and sex (Model 1: OR = 1.677, p = 0.022 and OR = 1.701, p = 0.021, respectively). The significant associations of vitamin D status with EQ-VAS were maintained after adjustment for other possible covariates (Model 3: OR = 1.562, p = 0.044). Also, a trend of associations between vitamin D status and EQ-5D index were shown after adjustment for other covariates (Model3: OR = 1.681, p = 0.056). CONCLUSION: This is the first study to reveal that vitamin D status is independently associated with HRQOL in an older Korean population with knee osteoarthritis. Our results suggest that the maintenance of sufficient vitamin D status may be important to prevent QOL decline in older populations with knee osteoarthritis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent48-
dc.relation.isPartOfHEALTH AND QUALITY OF LIFE OUTCOMES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCausality-
dc.subject.MESHChild-
dc.subject.MESHComorbidity-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMobility Limitation-
dc.subject.MESHNutrition Assessment-
dc.subject.MESHOsteoarthritis, Knee/blood*-
dc.subject.MESHOsteoarthritis, Knee/epidemiology*-
dc.subject.MESHOsteoarthritis, Knee/prevention & control-
dc.subject.MESHOsteoarthritis, Knee/psychology-
dc.subject.MESHPrevalence-
dc.subject.MESHQuality of Life*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSelf Care-
dc.subject.MESHVitamin D/blood*-
dc.subject.MESHVitamin D Deficiency/blood-
dc.subject.MESHVitamin D Deficiency/epidemiology*-
dc.titleAssociation between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorHye-Jung Kim-
dc.contributor.googleauthorJee-Yon Lee-
dc.contributor.googleauthorTae-Jong Kim-
dc.contributor.googleauthorJi-Won Lee-
dc.identifier.doi10.1186/s12955-015-0245-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03196-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ00972-
dc.identifier.eissn1477-7525-
dc.identifier.pmid25927585-
dc.subject.keywordVitamin D-
dc.subject.keywordQuality of life-
dc.subject.keywordEQ-VAS-
dc.subject.keywordEQ-5D-
dc.subject.keywordOsteoarthritis, knee-
dc.contributor.alternativeNameLee, Jee Yon-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.affiliatedAuthorLee, Jee Yon-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.rights.accessRightsfree-
dc.citation.volume13-
dc.citation.startPage48-
dc.identifier.bibliographicCitationHEALTH AND QUALITY OF LIFE OUTCOMES, Vol.13 : 48, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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