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Pain palliation in patients with bone metastases using magnetic resonance-guided focused ultrasound with conformal bone system: a preliminary report.

 Bio Joo  ;  Mi-Suk Park  ;  Soo Hyeon Lee  ;  Hye Jin Choi  ;  Seung Tack Lim  ;  Sun Young Rha  ;  Itay Rachmilevitch  ;  Young Han Lee  ;  Jin-Suck Suh 
 YONSEI MEDICAL JOURNAL, Vol.56(2) : 503-509, 2015 
Journal Title
Issue Date
Adult ; Aged ; Bone Neoplasms/secondary ; Bone Neoplasms/therapy* ; Contrast Media ; Female ; High-Intensity Focused Ultrasound Ablation/adverse effects ; High-Intensity Focused Ultrasound Ablation/methods* ; Humans ; Magnetic Resonance Imaging, Interventional/methods* ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Pain ; Pain Management* ; Palliative Care* ; Prospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
Magnetic Resonance-guided Focused Ultrasound ; bone metastases ; high-intensity focused ultrasound ; pain palliation
PURPOSE: We evaluated the safety and effectiveness of the Magnetic Resonance-guided Focused Ultrasound (MRgFUS) with the ExAblate Conformal Bone System for the palliation of painful bone metastases. MATERIALS AND METHODS: Our Institutional Review Board approved this study, and all patients gave informed consent prior to enrollment. A total of six painful metastatic bone lesions in five patients were treated using MRgFUS with the ExAblate Conformal Bone System for pain palliation. The follow-up sessions were at 3 days, 2 weeks, 1, 2, and 3 months, and 1 year after treatment. Efficacy was evaluated by the changes in visual analog scale (VAS) scores. At 3-months and 1-year follow-ups, unenhanced computed tomography and contrast-enhanced MR imaging examinations were performed. All adverse events were assessed to evaluate treatment safety. RESULTS: All patients showed significant pain relief within 2 weeks. Two patients experienced complete pain reduction that lasted for 1 year. Two other patients showed pain relief measured as VAS scores of 2 and 4 on their last follow-up. Although the remaining patient had experienced significant pain relief in two lesions, the VAS score re-increased on his last follow-up. The size of the enhancing soft tissue mass in metastatic lesions decreased, and new bone formation was seen on follow-up images. Although adverse events were not serious, non-specific leg pain and second degree skin burn were noted. CONCLUSION: MRgFUS was demonstrated to be effective palliative treatment within 2 weeks in selected patients with painful bone metastases.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Lim, Seung Taek(임승택)
Choi, Hye Jin(최혜진) ORCID logo https://orcid.org/0000-0001-5917-1400
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