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Mean platelet volume is elevated in patients with psoriasis vulgaris

Authors
 Dae Suk Kim  ;  Jungsoo Lee  ;  Sung Hee Kim  ;  Soo Min Kim  ;  Min-Geol Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.56(3) : 712-718, 2015 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2015
MeSH
Adult ; Blood Sedimentation ; Cross-Sectional Studies ; Female ; Humans ; Male ; Mean Platelet Volume* ; Middle Aged ; Platelet Count ; Psoriasis/blood* ; Psoriasis/physiopathology* ; Retrospective Studies ; Severity of Illness Index
Keywords
Psoriasis ; mean platelet volume ; platelet distribution width
Abstract
PURPOSE: This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity. MATERIALS AND METHODS: We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compared. RESULTS: Platelet distribution width and MPV were significantly higher in patients with psoriasis than controls. In addition, there was positive correlation between Psoriasis Area Severity Index (PASI) and MPV. When psoriasis patients were grouped into mild psoriasis (PASI<10) and moderate to severe psoriasis (PASI≥10), the MPV of the latter group was significantly elevated. Nevertheless, patients with higher MPV level (MPV≥10.4 fL) did not show higher PASI than lower MPV level (MPV<10.4 fL). MPV levels significantly decreased after improvements of psoriasis with various treatments. The variations of MPV and PASI also showed significant correlation. CONCLUSION: We have shown that MPV is increased in psoriasis patients and correlates with disease severity. Therefore, MPV levels may be considered as a marker of disease severity of psoriasis.
Files in This Item:
T201501356.pdf Download
DOI
10.3349/ymj.2015.56.3.712
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Suk(김대석)
Kim, Sung Hee(김성희)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140059
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