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Anti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans

 Su Jin Jeong  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Chang Oh Kim  ;  Young Goo Song  ;  June Myung Kim 
 Clinica Chimica Acta, Vol.445 : 65-69, 2015 
Journal Title
 Clinica Chimica Acta 
Issue Date
Aged ; Aged, 80 and over ; Antibodies, Viral/blood* ; Biomarkers/blood ; Carotid Arteries/immunology ; Carotid Arteries/metabolism ; Carotid Arteries/pathology ; Carotid Arteries/virology* ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnosis* ; Carotid Artery Diseases/immunology ; Carotid Intima-Media Thickness ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/blood ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis* ; Cytomegalovirus Infections/immunology ; Female ; Humans ; Immunoglobulin G/blood* ; Interleukin-1beta/blood ; Logistic Models ; Male ; Prospective Studies ; Republic of Korea ; Risk Factors ; Thyroxine/blood ; Tumor Necrosis Factor-alpha/blood
Carotid atherosclerosis ; Cytomegalovirus ; Elderly patients ; Inflammatory cytokines
BACKGROUND: Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans. METHODS: Participants (age, ≥65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT). RESULTS: Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p=0.003), Framingham score (OR 1.14, p=0.018), and levels of IL-1β (OR 2.96, p=0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r=0.523, p<0.001), free T4 levels (r=0.315, p=0.021), and Log(TNF-α) (r=0.562, p<0.001) in multivariate correlation analysis. CONCLUSIONS: These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
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