Cited 18 times in
Anti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans
DC Field | Value | Language |
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dc.contributor.author | 구남수 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 한상훈 | - |
dc.date.accessioned | 2016-02-04T11:15:20Z | - |
dc.date.available | 2016-02-04T11:15:20Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140014 | - |
dc.description.abstract | BACKGROUND: Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans. METHODS: Participants (age, ≥65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT). RESULTS: Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p=0.003), Framingham score (OR 1.14, p=0.018), and levels of IL-1β (OR 2.96, p=0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r=0.523, p<0.001), free T4 levels (r=0.315, p=0.021), and Log(TNF-α) (r=0.562, p<0.001) in multivariate correlation analysis. CONCLUSIONS: These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 65~69 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antibodies, Viral/blood* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Carotid Arteries/immunology | - |
dc.subject.MESH | Carotid Arteries/metabolism | - |
dc.subject.MESH | Carotid Arteries/pathology | - |
dc.subject.MESH | Carotid Arteries/virology* | - |
dc.subject.MESH | Carotid Artery Diseases/blood | - |
dc.subject.MESH | Carotid Artery Diseases/complications | - |
dc.subject.MESH | Carotid Artery Diseases/diagnosis* | - |
dc.subject.MESH | Carotid Artery Diseases/immunology | - |
dc.subject.MESH | Carotid Intima-Media Thickness | - |
dc.subject.MESH | Cytomegalovirus/immunology | - |
dc.subject.MESH | Cytomegalovirus Infections/blood | - |
dc.subject.MESH | Cytomegalovirus Infections/complications | - |
dc.subject.MESH | Cytomegalovirus Infections/diagnosis* | - |
dc.subject.MESH | Cytomegalovirus Infections/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin G/blood* | - |
dc.subject.MESH | Interleukin-1beta/blood | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Thyroxine/blood | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood | - |
dc.title | Anti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.1016/j.cca.2015.03.015 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04286 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 25797894 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898115001473 | - |
dc.subject.keyword | Carotid atherosclerosis | - |
dc.subject.keyword | Cytomegalovirus | - |
dc.subject.keyword | Elderly patients | - |
dc.subject.keyword | Inflammatory cytokines | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 445 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 69 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.445 : 65-69, 2015 | - |
dc.identifier.rimsid | 49029 | - |
dc.type.rims | ART | - |
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