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Anti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans

DC FieldValueLanguage
dc.contributor.author구남수-
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author송영구-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2016-02-04T11:15:20Z-
dc.date.available2016-02-04T11:15:20Z-
dc.date.issued2015-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140014-
dc.description.abstractBACKGROUND: Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans. METHODS: Participants (age, ≥65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT). RESULTS: Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p=0.003), Framingham score (OR 1.14, p=0.018), and levels of IL-1β (OR 2.96, p=0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r=0.523, p<0.001), free T4 levels (r=0.315, p=0.021), and Log(TNF-α) (r=0.562, p<0.001) in multivariate correlation analysis. CONCLUSIONS: These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals.-
dc.description.statementOfResponsibilityopen-
dc.format.extent65~69-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntibodies, Viral/blood*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCarotid Arteries/immunology-
dc.subject.MESHCarotid Arteries/metabolism-
dc.subject.MESHCarotid Arteries/pathology-
dc.subject.MESHCarotid Arteries/virology*-
dc.subject.MESHCarotid Artery Diseases/blood-
dc.subject.MESHCarotid Artery Diseases/complications-
dc.subject.MESHCarotid Artery Diseases/diagnosis*-
dc.subject.MESHCarotid Artery Diseases/immunology-
dc.subject.MESHCarotid Intima-Media Thickness-
dc.subject.MESHCytomegalovirus/immunology-
dc.subject.MESHCytomegalovirus Infections/blood-
dc.subject.MESHCytomegalovirus Infections/complications-
dc.subject.MESHCytomegalovirus Infections/diagnosis*-
dc.subject.MESHCytomegalovirus Infections/immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin G/blood*-
dc.subject.MESHInterleukin-1beta/blood-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHThyroxine/blood-
dc.subject.MESHTumor Necrosis Factor-alpha/blood-
dc.titleAnti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1016/j.cca.2015.03.015-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00189-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA02037-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid25797894-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009898115001473-
dc.subject.keywordCarotid atherosclerosis-
dc.subject.keywordCytomegalovirus-
dc.subject.keywordElderly patients-
dc.subject.keywordInflammatory cytokines-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume445-
dc.citation.startPage65-
dc.citation.endPage69-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.445 : 65-69, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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