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Associations between Genetic Variants and Angiographic Characteristics in Patients with Coronary Artery Disease

Authors
 Ji-Young Lee  ;  Gwangsil Kim  ;  Sungha Park  ;  Seok-Min Kang  ;  Yangsoo Jang  ;  Sang-Hak Lee 
Citation
 Journal of Atherosclerosis and Thromobosis, Vol.22(4) : 363-371, 2015 
Journal Title
 Journal of Atherosclerosis and Thromobosis 
ISSN
 1340-3478 
Issue Date
2015
Abstract
AIM: In this study, we investigated the genetic determinants of lesion characteristics and the severity of coronary artery disease (CAD) using a genome-wide association study (GWAS) and replication genotyping. METHODS: The discovery set for GWAS consisted of 667 patients exhibiting angiographically diagnosed CAD with symptoms. For replication genotyping, 837 age- and sex-matched CAD patients were selected. Genetic determinants of lesion characteristics (diffuse vs. non-diffuse lesions), the number of diseased vessels (multi-vessel vs. single vessel disease) and the modified Duke score (high vs. low), which indicates the severity of CAD, were analyzed after adjusting for confounding factors. RESULTS: Single nucleotide polymorphisms (SNPs) rs12917449, rs10152898 and rs231150 were associated with diffuse lesions, while rs1225006 and rs6745588 were associated with multi-vessel disease. However, on replication genotyping, no significant associations were found between any of these five SNPs and the lesion characteristics or CAD severity. In contrast, in the combined population of both the discovery and replication sets, genotypes rs125006 of CPNE4 and rs231150 of TRPS1 were found to be significantly associated with the modified Duke score. The addition of rs1225006 to conventional risk factors had significant incremental value in the model of the score. CONCLUSIONS: The associations between five SNPs identified using GWAS and angiographic characteristics were not significant in the current replication study. However, two variants, particularly rs1225006, were found to be associated with the severity of CAD in the combined set. These results indicate the potential clinical implication of these variants with respect to the risk of CAD.
Files in This Item:
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DOI
10.5551/jat.26047
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
강석민(Kang, Seok Min) ORCID logo https://orcid.org/0000-0001-9856-9227
김광실(Kim, Gwang Sil)
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
이상학(Lee, Sang Hak) ORCID logo https://orcid.org/0000-0002-4535-3745
이지영(Lee, Ji Young) ORCID logo https://orcid.org/0000-0002-7784-1401
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139970
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