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Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

Authors
 Jongsoo Kim  ;  Hyo Jung Yun  ;  Ji Yeon Lee  ;  Myoung Hee Kim 
Citation
 Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.21(1) : 15-22, 2015 
Journal Title
Journal of Experimental & Biomedcal Science(대한의생명과학회지)
ISSN
 1738-3226 
Issue Date
2015
MeSH
Animals ; Antioxidants/administration & dosage ; Body Weight/drug effects ; Bone Density/drug effects ; Bone and Bones/abnormalities ; Bone and Bones/drug effects* ; Bone and Bones/metabolism ; Crown-Rump Length ; Diet, Atherogenic* ; Embryo, Mammalian/abnormalities ; Embryo, Mammalian/drug effects* ; Embryo, Mammalian/metabolism ; Fatty Acids/administration & dosage* ; Female ; Fetal Weight/drug effects ; Image Processing, Computer-Assisted ; Male ; Maternal Exposure ; Mice ; Mice, Inbred C57BL ; Osteogenesis/drug effects* ; Oxidative Stress/drug effects ; Quercetin/analysis ; Tomography, X-Ray Computed
Keywords
gestational high saturated fat diet ; perinatal skeletal formation ; C57BL/6 mice
Abstract
Dexamethasone, a synthetic glucocorticoid (GC), is clinically administered to woman at risk for premature labor to induce fetal lung maturation. However, exposure to repeated or excess GCs leads to intrauterine growth restriction (IUGR) and subsequently increases risk of psychiatric and cardio-metabolic diseases in later life through fetal programming mechanisms. GCs are key mediators of stress responses, therefore, maternal nutrient restriction or psychological stress during pregnancy also causes negative impacts on birth and neurodevelopment outcome of fetuses, and other congenital defects, such as craniofacial and skeletal abnormalities. In this study, to examine the effect of prenatal stress on fetal skeletal development, dexamethasone (1 mg/kg [DEX1] or 10 mg/kg [DEX10] maternal body weight per day) was administered intraperitoneally at gestational day 7.5~9.5 and the skeletons were prepared from embryos at day 18.5. Seven out of eighteen (39%) embryos treated with DEX10 showed axial skeletal abnormalities in either the T13 or L1 vertebrae. In addition, examination of the sternum revealed that xiphoid process, the protrusive triangular part of the lower end of the sternum, was bent more outward or inward in DEX group embryos. In conclusion, our findings suggest a possible link to the understanding of the effect of uterine environment to the fetal skeletal features.
Files in This Item:
T201500868.pdf Download
DOI
10.15616/BSL.2015.21.1.15
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Lee, Ji Yeon(이지연) ORCID logo https://orcid.org/0000-0002-0670-3095
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139775
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