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Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

DC Field Value Language
dc.contributor.author김명희-
dc.contributor.author이지연-
dc.date.accessioned2016-02-04T11:08:58Z-
dc.date.available2016-02-04T11:08:58Z-
dc.date.issued2015-
dc.identifier.issn1738-3226-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139775-
dc.description.abstractDexamethasone, a synthetic glucocorticoid (GC), is clinically administered to woman at risk for premature labor to induce fetal lung maturation. However, exposure to repeated or excess GCs leads to intrauterine growth restriction (IUGR) and subsequently increases risk of psychiatric and cardio-metabolic diseases in later life through fetal programming mechanisms. GCs are key mediators of stress responses, therefore, maternal nutrient restriction or psychological stress during pregnancy also causes negative impacts on birth and neurodevelopment outcome of fetuses, and other congenital defects, such as craniofacial and skeletal abnormalities. In this study, to examine the effect of prenatal stress on fetal skeletal development, dexamethasone (1 mg/kg [DEX1] or 10 mg/kg [DEX10] maternal body weight per day) was administered intraperitoneally at gestational day 7.5~9.5 and the skeletons were prepared from embryos at day 18.5. Seven out of eighteen (39%) embryos treated with DEX10 showed axial skeletal abnormalities in either the T13 or L1 vertebrae. In addition, examination of the sternum revealed that xiphoid process, the protrusive triangular part of the lower end of the sternum, was bent more outward or inward in DEX group embryos. In conclusion, our findings suggest a possible link to the understanding of the effect of uterine environment to the fetal skeletal features.-
dc.description.statementOfResponsibilityopen-
dc.format.extent15~22-
dc.relation.isPartOfJournal of Experimental & Biomedcal Science (대한의생명과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/administration & dosage-
dc.subject.MESHBody Weight/drug effects-
dc.subject.MESHBone Density/drug effects-
dc.subject.MESHBone and Bones/abnormalities-
dc.subject.MESHBone and Bones/drug effects*-
dc.subject.MESHBone and Bones/metabolism-
dc.subject.MESHCrown-Rump Length-
dc.subject.MESHDiet, Atherogenic*-
dc.subject.MESHEmbryo, Mammalian/abnormalities-
dc.subject.MESHEmbryo, Mammalian/drug effects*-
dc.subject.MESHEmbryo, Mammalian/metabolism-
dc.subject.MESHFatty Acids/administration & dosage*-
dc.subject.MESHFemale-
dc.subject.MESHFetal Weight/drug effects-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMale-
dc.subject.MESHMaternal Exposure-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHOsteogenesis/drug effects*-
dc.subject.MESHOxidative Stress/drug effects-
dc.subject.MESHQuercetin/analysis-
dc.subject.MESHTomography, X-Ray Computed-
dc.titlePrenatal Stress Induces Skeletal Malformations in Mouse Embryos-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorJongsoo Kim-
dc.contributor.googleauthorHyo Jung Yun-
dc.contributor.googleauthorJi Yeon Lee-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.15616/BSL.2015.21.1.15-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00432-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ01408-
dc.identifier.pmid19750487-
dc.subject.keywordgestational high saturated fat diet-
dc.subject.keywordperinatal skeletal formation-
dc.subject.keywordC57BL/6 mice-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.affiliatedAuthorKim, Myoung Hee-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage15-
dc.citation.endPage22-
dc.identifier.bibliographicCitationJournal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.21(1) : 15-22, 2015-
dc.identifier.rimsid53813-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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