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Effects of agmatine on blood-brain barrier stabilization assessed by permeability MRI in a rat model of transient cerebral ischemia

DC Field Value Language
dc.contributor.author김동준-
dc.contributor.author김세훈-
dc.contributor.author김진아-
dc.contributor.author신나영-
dc.contributor.author안성수-
dc.contributor.author이승구-
dc.contributor.author이종은-
dc.date.accessioned2016-02-04T11:08:53Z-
dc.date.available2016-02-04T11:08:53Z-
dc.date.issued2015-
dc.identifier.issn0195-6108-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139772-
dc.description.abstractBACKGROUND AND PURPOSE: BBB disruption after acute ischemic stroke and subsequent permeability increase may be enhanced by reperfusion. Agmatine has been reported to attenuate BBB disruption. Our aim was to evaluate the effects of agmatine on BBB stabilization in a rat model of transient cerebral ischemia by using permeability dynamic contrast-enhanced MR imaging at early stages and subsequently to demonstrate the feasibility of dynamic contrast-enhanced MR imaging for the investigation of new therapies. MATERIALS AND METHODS: Thirty-four male Sprague-Dawley rats were subjected to transient MCA occlusion for 90 minutes. Immediately after reperfusion, agmatine (100 mg/kg) or normal saline was injected intraperitoneally into the agmatine-treated group (n = 17) or the control group, respectively. MR imaging was performed after reperfusion. For quantitative analysis, regions of interest were defined within the infarct area, and values for volume transfer constant, rate transfer coefficient, volume fraction of extravascular extracellular space, and volume fraction of blood plasma were obtained. Infarct volume, infarct growth, quantitative imaging parameters, and numbers of factor VIII-positive cells after immunohistochemical staining were compared between control and agmatine-treated groups. RESULTS: Among the permeability parameters, volume transfer constant and volume fraction of extravascular extracellular space were significantly lower in the agmatine-treated group compared with the control group (0.05 ± 0.02 minutes(-1) versus 0.08 ± 0.03 minute(-1), P = .012, for volume transfer constant and 0.12 ± 0.06 versus 0.22 ± 0.15, P = .02 for volume fraction of extravascular extracellular space). Other permeability parameters were not significantly different between the groups. The number of factor VIII-positive cells was less in the agmatine-treated group than in the control group (3-fold versus 4-fold, P = .037). CONCLUSIONS: In ischemic stroke, agmatine protects the BBB, which can be monitored in vivo by quantification of permeability by using dynamic contrast-enhanced MR imaging. Therefore, dynamic contrast-enhanced MR imaging may serve as a potential imaging biomarker for assessing the BBB stabilization properties of pharmacologic agents.-
dc.description.statementOfResponsibilityopen-
dc.format.extent283~288-
dc.relation.isPartOfAMERICAN JOURNAL OF NEURORADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAgmatine/pharmacology*-
dc.subject.MESHAnimals-
dc.subject.MESHBlood-Brain Barrier/drug effects*-
dc.subject.MESHBlood-Brain Barrier/physiopathology-
dc.subject.MESHCapillary Permeability/drug effects*-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHInfarction, Middle Cerebral Artery/physiopathology*-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.titleEffects of agmatine on blood-brain barrier stabilization assessed by permeability MRI in a rat model of transient cerebral ischemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorS.S. Ahn-
dc.contributor.googleauthorS.H. Kim-
dc.contributor.googleauthorJ.E. Lee-
dc.contributor.googleauthorK.J. Ahn-
dc.contributor.googleauthorD.J. Kim-
dc.contributor.googleauthorH.S. Choi-
dc.contributor.googleauthorJ. Kim-
dc.contributor.googleauthorN.-Y. Shin-
dc.contributor.googleauthorS.-K. Lee-
dc.identifier.doi10.3174/ajnr.A4113-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00410-
dc.contributor.localIdA00610-
dc.contributor.localIdA02089-
dc.contributor.localIdA02912-
dc.contributor.localIdA03146-
dc.contributor.localIdA02234-
dc.contributor.localIdA01022-
dc.relation.journalcodeJ00095-
dc.identifier.eissn1936-959X-
dc.identifier.pmid25273536-
dc.identifier.urlhttp://www.ajnr.org/content/36/2/283.long-
dc.contributor.alternativeNameKim, Dong Joon-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Jinna-
dc.contributor.alternativeNameShin, Na Young-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameLee, Jong Eun-
dc.contributor.affiliatedAuthorKim, Dong Joon-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorShin, Na Young-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorLee, Jong Eun-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorKim, Jinna-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number2-
dc.citation.startPage283-
dc.citation.endPage288-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF NEURORADIOLOGY, Vol.36(2) : 283-288, 2015-
dc.identifier.rimsid53810-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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