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Evaluation of serum thyroid-stimulating hormone as indicator for fine-needle aspiration in patients with thyroid nodules

Authors
 Ji Soo Choi  ;  Chung Mo Nam  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Kyung Hwa Han  ;  Jin Young Kwak 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.37(4) : 498-504, 2015 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2015
MeSH
Aged ; Algorithms ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Thyroid Gland/diagnostic imaging ; Thyroid Nodule/blood* ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology* ; Thyrotropin/blood*
Keywords
diagnosis ; thyroid malignancy ; thyroid nodule ; thyroid-stimulating hormone (TSH) ; ultrasound
Abstract
BACKGROUND: Recently, it has been reported that the risk of thyroid malignancy increases with increasing concentrations of serum thyroid-stimulating hormone (TSH). The purpose of this study was to determine whether or not serum TSH can be a predictor for thyroid malignancy when considering the relevant ultrasound features and clinical risk factors. METHODS: This retrospective study included 1200 euthyroid patients with 1269 thyroid nodules who underwent ultrasound-guided fine-needle aspiration (FNA) biopsy between January and June 2009. Serum TSH, ultrasound feature, and clinical parameters were compared according to final diagnosis. Subgroup analyses were performed according to nodule size. RESULTS: Serum TSH did not show a positive association with malignancy for all nodules and the micronodule subgroup in multivariate analysis, although they showed significant association with thyroid malignancy for the macronodule subgroup. For all nodules and the 2 subgroups, suspicious ultrasound features and younger age were significantly associated with malignancy in univariate and multivariate analyses. CONCLUSION: Our study suggests that TSH alone is not as useful as ultrasound features in deciding whether or not to perform FNA in patients with micronodules.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23616/abstract
DOI
10.1002/hed.23616
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139722
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