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VvpM induces human cell death via multifarious modes including necroptosis and autophagy

Authors
 Mi Ae Lee  ;  Jeong A Kim  ;  Mee Young Shin  ;  Jeong K Lee  ;  Soon Jung Park  ;  Kyu Ho Lee 
Citation
 JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.25(2) : 302-306, 2015 
Journal Title
 JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 
ISSN
 1017-7825 
Issue Date
2015
MeSH
Apoptosis* ; Autophagy* ; Caspase 3/metabolism ; Caspases/metabolism ; Cell Death* ; Cell Line, Tumor ; Cell Survival ; Cytochromes c/metabolism ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Metalloproteases/metabolism* ; Necrosis ; Vibrio vulnificus/enzymology* ; Vibrio vulnificus/metabolism ; Vibrio vulnificus/pathogenicity*
Keywords
Vibrio vulnificus ; metalloprotease VvpM ; necroptosis ; autophagy
Abstract
VvpM, one of the extracellular metalloproteases produced by Vibrio vulnificus, induces apoptotic cell death via a pathway consisting of ERK activation, cytochrome c release, and activation of caspases-9 and -3. VvpM-treated cells also showed necrotic cell death as stained by propidium iodide (PI). The percentage of PI-stained cells was decreased by pretreatment with Necrostatin-1, indicating that VvpM-mediated cell death occurs through necroptosis. The appearance of autophagic vesicles and lipidated form of light-chain-3B in rVvpM-treated cells suggests an involvement of autophagy in this process. Therefore, the multifarious action of VvpM might be one of the factors responsible for V. vulnificus pathogenesis.
Files in This Item:
T201500769.pdf Download
DOI
10.4014/jmb.1501.01007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Soon Jung(박순정) ORCID logo https://orcid.org/0000-0002-0423-1944
Shin, Mee Young(신미영) ORCID logo https://orcid.org/0000-0003-3676-2683
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139682
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