Cited 7 times in
VvpM induces human cell death via multifarious modes including necroptosis and autophagy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박순정 | - |
dc.contributor.author | 신미영 | - |
dc.date.accessioned | 2016-02-04T11:06:32Z | - |
dc.date.available | 2016-02-04T11:06:32Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139682 | - |
dc.description.abstract | VvpM, one of the extracellular metalloproteases produced by Vibrio vulnificus, induces apoptotic cell death via a pathway consisting of ERK activation, cytochrome c release, and activation of caspases-9 and -3. VvpM-treated cells also showed necrotic cell death as stained by propidium iodide (PI). The percentage of PI-stained cells was decreased by pretreatment with Necrostatin-1, indicating that VvpM-mediated cell death occurs through necroptosis. The appearance of autophagic vesicles and lipidated form of light-chain-3B in rVvpM-treated cells suggests an involvement of autophagy in this process. Therefore, the multifarious action of VvpM might be one of the factors responsible for V. vulnificus pathogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 302~306 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Caspases/metabolism | - |
dc.subject.MESH | Cell Death* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cytochromes c/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imidazoles/pharmacology | - |
dc.subject.MESH | Indoles/pharmacology | - |
dc.subject.MESH | Metalloproteases/metabolism* | - |
dc.subject.MESH | Necrosis | - |
dc.subject.MESH | Vibrio vulnificus/enzymology* | - |
dc.subject.MESH | Vibrio vulnificus/metabolism | - |
dc.subject.MESH | Vibrio vulnificus/pathogenicity* | - |
dc.title | VvpM induces human cell death via multifarious modes including necroptosis and autophagy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Mi Ae Lee | - |
dc.contributor.googleauthor | Jeong A Kim | - |
dc.contributor.googleauthor | Mee Young Shin | - |
dc.contributor.googleauthor | Jeong K Lee | - |
dc.contributor.googleauthor | Soon Jung Park | - |
dc.contributor.googleauthor | Kyu Ho Lee | - |
dc.identifier.doi | 10.4014/jmb.1501.01007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01545 | - |
dc.contributor.localId | A02101 | - |
dc.relation.journalcode | J01594 | - |
dc.identifier.eissn | 1738-8872 | - |
dc.identifier.pmid | 25649984 | - |
dc.subject.keyword | Vibrio vulnificus | - |
dc.subject.keyword | metalloprotease VvpM | - |
dc.subject.keyword | necroptosis | - |
dc.subject.keyword | autophagy | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.alternativeName | Shin, Mee Young | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Shin, Mee Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 302 | - |
dc.citation.endPage | 306 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.25(2) : 302-306, 2015 | - |
dc.identifier.rimsid | 52949 | - |
dc.type.rims | ART | - |
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