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The Effect of Low-Dose β-Blocker on Heart Rate and Heart Rate Variability in Healthy Subjects with a Resting Heart Rate of Less than 65 Beats per Minute: Effect on the Image Quality of Prospective Electrocardiography-Gated Coronary CT Angiography1

Other Titles
 저용량 베타차단제가 낮은 심박수 무증상 환자의 심박수, 심박변화, 그리고 전향적 동조화 심장 CT에 미치는 영향1 
 Chul Hwan Park  ;  Sang Min Lee  ;  Yoo Jin Hong  ;  Tae Hoon Kim 
 Journal of the Korean Radiological Society (대한영상의학회지), Vol.72(2) : 83-91, 2015 
Journal Title
 Journal of the Korean Radiological Society (대한영상의학회지) 
Issue Date
β-Blocker ; Coronary CT Angiography ; Heart Rate ; Heart Rate Variability ; Image Quality
Purpose : We assessed the effect of a low-dose β-blocker on heart rate (HR), HR variability (HRV) and image quality of prospective electrocardiography-gated coronary CT angiography (CCTA) in healthy subjects with low HR. Materials and Methods : CCTA was performed with a 64-slice CT in 75 subjects with a HR of less than 65 beats per minute (bpm). Subjects were divided into 2 groups: Group 1 (G1), 35 with a low dose β-blocker; and Group 2 (G2), 40 without pre-medication. The image quality (IQ) of the CCTA was assessed on a 4-point grading scale (1, poor; 4, excellent). Results : Initial HR (bpm) was not different between the 2 groups. HR during CCTA was lower in G1 than G2 (50.3 ± 5.6 vs. 53.3 ± 4.8, p = 0.016). HRV was not different between the 2 groups. Per-segment analysis showed better IQ at the mid-segment of the right coronary artery (3.0 ± 0.9 vs. 2.5 ± 1.1, p = 0.039) and the first diagonal branch (3.4 ± 0.6 vs. 3.1 ± 0.7, p = 0.024), in the G1 than the G2 group, respectively. The IQ was negatively correlated with HR, but no correlation was found between HRV and IQ. The IQs in the per-vessel analysis were not different between the 2 groups. Conclusion : Low-dose β-blocker reduced HR and improved the IQ of CCTA in a few segments, even at a HR of less than 65 bpm. However the effect was limited.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
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