327 309

Cited 14 times in

Evaluation of antigen-specific immunoglobulin g responses in pulmonary tuberculosis patients and contacts

DC FieldValueLanguage
dc.contributor.author김영미-
dc.contributor.author조상래-
dc.contributor.author허윤경-
dc.contributor.author강영애-
dc.contributor.author김아름-
dc.date.accessioned2016-02-04T11:03:55Z-
dc.date.available2016-02-04T11:03:55Z-
dc.date.issued2015-
dc.identifier.issn0095-1137-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139584-
dc.description.abstractThis study aimed to evaluate the serodiagnostic potential of immunoglobulin G (IgG) responses to Mycobacterium tuberculosis antigens in pulmonary tuberculosis (TB) patients, recent TB contacts with latent TB infection (LTBI), and healthy subjects. Infections were assessed using tuberculin skin tests, QuantiFERON-TB Gold In-Tube tests, drug susceptibility testing, and molecular genotyping of clinical isolates. Serum IgG responses to selective M. tuberculosis antigens, including the 38-kDa and 16-kDa antigens, lipoarabinomannan (LAM), and recombinant early secreted antigen target 6 kDa (ESAT-6) and culture filtrate protein 10 kDa (CFP-10), were determined. We found that the serum IgG responses to all antigens might differentiate between active TB and LTBI, with LAM having the highest diagnostic value (area under the curve [AUC] of 0.7756, P < 0.001). Recurrent TB cases showed significantly higher IgG responses to 38 kDa, CFP-10 (P < 0.01), and LAM (P < 0.05) than new cases, and male patients had higher levels of antigen-specific IgG than females (P < 0.05). Conversely, drug resistance and patient body mass index did not affect IgG responses (P > 0.05). LAM-specific IgG responses differentiated between acid-fast bacillus (AFB) smear-positive and -negative patients (P < 0.01), whereas antigen-specific IgG responses did not vary with the M. tuberculosis genotype (P > 0.05). Significantly higher IgG responses to 38 kDa and 16 kDa were observed in AFB smear-negative patients than in controls. These results suggest that assessment of serum IgG responses to selective purified M. tuberculosis antigens may help improve the diagnosis of active TB, particularly for sputum smear-negative patients or recurrent cases, and these may also help to differentiate between active TB and LTBI.-
dc.description.statementOfResponsibilityopen-
dc.format.extent904~909-
dc.relation.isPartOfJOURNAL OF CLINICAL MICROBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntibodies, Bacterial/blood*-
dc.subject.MESHAntigens, Bacterial/immunology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin G/blood*-
dc.subject.MESHMale-
dc.subject.MESHMycobacterium tuberculosis/immunology*-
dc.subject.MESHSerologic Tests/methods-
dc.subject.MESHTuberculosis, Pulmonary/diagnosis-
dc.subject.MESHTuberculosis, Pulmonary/immunology*-
dc.titleEvaluation of antigen-specific immunoglobulin g responses in pulmonary tuberculosis patients and contacts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorYun-Gyoung Hur-
dc.contributor.googleauthorAhreum Kim-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorAn Sik Kim-
dc.contributor.googleauthorDae Yeon Kim-
dc.contributor.googleauthorYeun Kim-
dc.contributor.googleauthorYoungmi Kim-
dc.contributor.googleauthorHyeyoung Lee-
dc.contributor.googleauthorSang-Nae Cho-
dc.identifier.doi10.1128/JCM.03050-14-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00705-
dc.contributor.localIdA03824-
dc.contributor.localIdA00679-
dc.contributor.localIdA04701-
dc.relation.journalcodeJ01325-
dc.identifier.eissn1098-660X-
dc.identifier.pmid25588651-
dc.contributor.alternativeNameKim, Young Mi-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.alternativeNameHur, Yun Gyoung-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Ah Reum-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Young Mi-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.contributor.affiliatedAuthorKim, Ah Reum-
dc.contributor.affiliatedAuthorHur, Yun-Gyoung-
dc.rights.accessRightsfree-
dc.citation.volume53-
dc.citation.number3-
dc.citation.startPage904-
dc.citation.endPage909-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MICROBIOLOGY, Vol.53(3) : 904-909, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.