253 273

Cited 3 times in

Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

DC FieldValueLanguage
dc.contributor.author김명준-
dc.contributor.author김현지-
dc.contributor.author박규리-
dc.contributor.author신현주-
dc.contributor.author이미정-
dc.contributor.author이혜선-
dc.contributor.author장은영-
dc.contributor.author홍정화-
dc.date.accessioned2016-02-04T11:03:44Z-
dc.date.available2016-02-04T11:03:44Z-
dc.date.issued2015-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139577-
dc.description.abstractAIM: To investigate perfusion change in contrast-enhanced ultrasonography (CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal model. METHODS: New Zealand white rabbits (3-4 kg) underwent bile duct ligation to form a biliary obstruction model. We performed liver CEUS and laboratory tests on the day before the operation (day 0) and every 7 postoperative days until the rabbits were sacrificed. After CEUS, signal intensity of liver parenchyma with a time-intensity curve was analyzed. Perfusion parameters were automatically calculated from region-of-interests, including peak signal intensity, mean transit time, area under the curve and time to peak. Histological grades of liver fibrosis were assessed according to the Metavir score system immediately after sacrifice. Generalized estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical analysis. The perfusion parameters were measured on the last day and the difference between day 0 and the last day were evaluated. RESULTS: From the nine rabbits, histological grades of liver fibrosis were grade 1 in one rabbit, grade 2 and 3 in three rabbits each, and grade 4 in two rabbits. Among the four CEUS parameters, only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades (OR = 1.392, 95%CI: 1.114-1.741, P = 0.004). The difference in peak signal intensity between day 0 and the last day also demonstrated an association with liver fibrosis (OR = 1.191, 95%CI: 0.999-1.419, P = 0.051). The other parameters tested, including mean transit time, area under the curve, and time to peak, showed no significant correlation with liver fibrosis grades. CONCLUSION: This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2614~2621-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCholestasis/complications*-
dc.subject.MESHContrast Media*-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHLiver/blood supply*-
dc.subject.MESHLiver/diagnostic imaging*-
dc.subject.MESHLiver Circulation*-
dc.subject.MESHLiver Cirrhosis, Experimental/diagnostic imaging*-
dc.subject.MESHLiver Cirrhosis, Experimental/etiology-
dc.subject.MESHLiver Cirrhosis, Experimental/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMicrocirculation-
dc.subject.MESHPerfusion Imaging/methods*-
dc.subject.MESHPhospholipids*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRabbits-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSulfur Hexafluoride*-
dc.subject.MESHTime Factors-
dc.subject.MESHUltrasonography-
dc.titleContrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorHyun Joo Shin-
dc.contributor.googleauthorEun Young Chang-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorGyuri Park-
dc.contributor.googleauthorHyun Gi Kim-
dc.contributor.googleauthorMyung-Joon Kim-
dc.contributor.googleauthorMi-Jung Lee-
dc.identifier.doi10.3748/wjg.v21.i9.2614-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03312-
dc.contributor.localIdA02774-
dc.contributor.localIdA00425-
dc.contributor.localIdA01139-
dc.contributor.localIdA01439-
dc.contributor.localIdA02178-
dc.contributor.localIdA03459-
dc.contributor.localIdA04433-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid25759528-
dc.subject.keywordAnimals-
dc.subject.keywordBile ducts-
dc.subject.keywordContrast enhanced ultrasound-
dc.subject.keywordLigation-
dc.subject.keywordLiver cirrhosis-
dc.subject.keywordRabbits-
dc.subject.keywordUltrasonography-
dc.contributor.alternativeNameKim, Myung Joon-
dc.contributor.alternativeNameKim, Hyun Gi-
dc.contributor.alternativeNamePark, Gyuri-
dc.contributor.alternativeNameShin, Hyun Joo-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameChang, Eun Young-
dc.contributor.alternativeNameHong, Jung Hwa-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorKim, Myung Joon-
dc.contributor.affiliatedAuthorKim, Hyun Gi-
dc.contributor.affiliatedAuthorPark, Gyuri-
dc.contributor.affiliatedAuthorShin, Hyun Joo-
dc.contributor.affiliatedAuthorChang, Eun Young-
dc.contributor.affiliatedAuthorHong, Jung Hwa-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number9-
dc.citation.startPage2614-
dc.citation.endPage2621-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.21(9) : 2614-2621, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.