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Feasibility of 5-minute delayed transition phase imaging with 30° flip angle in gadoxetic acid-enhanced 3D gradient-echo MRI of liver, compared with 20-minute delayed hepatocyte phase MRI with standard 10° flip angle

Authors
 Eun-Suk Cho  ;  Jeong-Sik Yu  ;  Ah Young Park  ;  SeungTae Woo  ;  Joo Hee Kim  ;  Jae-Joon Chung 
Citation
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.204(1) : 69-75, 2015 
Journal Title
AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN
 0361-803X 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; Algorithms ; Contrast Media/administration & dosage ; Feasibility Studies ; Female ; Gadolinium DTPA*/administration & dosage ; Hepatocytes/pathology ; Humans ; Image Enhancement/methods* ; Image Interpretation, Computer-Assisted/methods* ; Imaging, Three-Dimensional/methods* ; Liver Diseases/pathology* ; Magnetic Resonance Imaging/methods* ; Magnetic Resonance Imaging/standards ; Male ; Reproducibility of Results ; Republic of Korea ; Sensitivity and Specificity ; Time Factors
Keywords
MRI ; flip angle ; gadoxetic acid disodium ; hepatocyte phase ; liver
Abstract
OBJECTIVE: The purpose of this study was to compare 5-minute delayed transitional phase imaging using a 30° flip angle (hereafter, 5 min-FA30) and 20-minute hepatocyte phase imaging using a 10° flip angle (hereafter, 20 min-FA10) in gadoxetic acid-enhanced MRI for focal hepatic lesion detection and lesion-to-liver contrast-to-noise ratio (CNR), and to determine whether 5 min-FA30 could replace 20 min-FA10 with a 15-minute time saving.

MATERIALS AND METHODS: One hundred sixteen patients with 282 focal hepatic lesions (size range, 0.2-12.5 cm; malignant, n = 146; benign, n = 136) underwent gadoxetic acid-enhanced MRI with 5 min-FA30 and 20 min-FA10 with a 3D T1-weighted gradient-echo sequence. Three radiologists independently assessed the presence of focal hepatic lesions using a 4-point scale, and detection sensitivity of focal hepatic lesions was calculated. Lesion-to-liver CNRs were calculated and compared in two image groups.

RESULTS: There was no significant difference in detection sensitivity of focal hepatic lesions for all three readers between 5 min-FA30 (mean, 95.4%) and 20 min-FA10 (mean, 95.6%), irrespective of lesion size or malignancy. The mean CNR on 5 min-FA30 (167.9 ± 84.1) was significantly higher than that on 20 min-FA10 (160.2 ± 79.5). However, the mean CNR difference between the two image groups was relatively small (7.8 ± 41.9).

CONCLUSION: Compared with 20 min-FA10, 5 min-FA30 provided higher CNR and similar sensitivity. These findings indicate that 5 min-FA30 could replace 20-min delayed hepatocyte phase imaging using a 10° flip angle with similar diagnostic performance and 15 minutes of time saving.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.13.11903
DOI
10.2214/AJR.13.11903
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Park, Ah Young(박아영)
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Cho, Eun Suk(조은석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139572
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