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Effect of different hydroxyapatite:β-tricalcium phosphate ratios on the osteoconductivity of biphasic calcium phosphate in the rabbit sinus model

Authors
 Hyun-Chang Lim  ;  Ming-Lan Zhang  ;  Jung-Seok Lee  ;  Ui-Won Jung  ;  Seong-Ho Choi 
Citation
 INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, Vol.30(1) : 65-72, 2015 
Journal Title
 INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS 
ISSN
 0882-2786 
Issue Date
2015
MeSH
Absorbable Implants* ; Animals ; Bone Regeneration/physiology* ; Bone Substitutes/chemistry ; Bone Substitutes/therapeutic use* ; Disease Models, Animal ; Hydroxyapatites/chemistry ; Hydroxyapatites/therapeutic use* ; Materials Testing ; Osteogenesis/physiology* ; Paranasal Sinuses/physiology ; Paranasal Sinuses/surgery* ; Rabbits ; X-Ray Microtomography
Keywords
biphasic calcium ; phosphate ; bone regeneration ; rabbit sinus model ; sinus augmentation
Abstract
PURPOSE: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of (β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), i.e., 70:30 vs 30:70, in the rabbit sinus model. MATERIALS AND METHODS: Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA: β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2 weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography. RESULTS: The bone volume did not differ significantly between the two groups at each healing point, or between 2 and 8 weeks of healing in both groups. The amount of new bone increased significantly between 2 and 8 weeks of healing in both groups, and it did not differ significantly between the TCP30 and TCP70 groups. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant cells were observed at both weeks. The bone-to-residual material contact ratio did not differ significantly between the two groups. CONCLUSION: The volume stability and osteoconductive capacity of BCP with an HA: β-TCP ratio of 30:70 was comparable to that with an HA: β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be argued that BCP with an HA: β-TCP ratio of 30:70 can be successfully used for sinus augmentation.
Full Text
http://www.quintpub.com/journals/omi/abstract.php?article_id=15003#.VmjNznIw-Uk
DOI
10.11607/jomi.3709
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Periodontal Tissue Regeneration (치주조직재생연구소) > 1. Journal Papers
Yonsei Authors
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Lim, Hyun Chang(임현창)
Zhang, Ming Lan(장명란)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139568
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