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The relationship between hemodialysis modality and insulin resistance in non-diabetic hemodialysis patients

Authors
 Moon S.J.  ;  Lee J.E.  ;  Kim J.-K.  ;  Yoon S.Y.  ;  Kang S.W.  ;  Choi K.H.  ;  Ha S.K.  ;  Park H.-C. 
Citation
 BLOOD PURIFICATION, Vol.39(1-3) : 224-229, 2015 
Journal Title
 BLOOD PURIFICATION 
ISSN
 0253-5068 
Issue Date
2015
MeSH
Adult ; Age Factors ; Aged ; Blood Glucose/metabolism ; Body Mass Index ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Homeostasis ; Humans ; Insulin Resistance* ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy* ; Male ; Middle Aged ; Multivariate Analysis ; Renal Dialysis/methods* ; beta 2-Microglobulin/blood
Keywords
Hemodiafiltration ; Insulin resistance ; Hemodialysis ; End-stage renal disease
Abstract
BACKGROUND: Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. METHODS: In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. RESULTS: The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. CONCLUSION: This study suggests that HDF treatment may reduce IR in non-diabetic HD patients.
Full Text
http://www.karger.com/Article/FullText/368882
DOI
10.1159/000368882
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Ha, Sung Kyu(하성규)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139560
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