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Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project

Authors
 Bo Mi Song  ;  Ju-Mi Lee  ;  Wungrak Choi  ;  Yoosik Youm  ;  Sang Hui Chu  ;  Yeong-Ran Park  ;  Hyeon Chang Kim 
Citation
 BMJ OPEN, Vol.5(2) : 006429, 2015 
Journal Title
 BMJ OPEN 
Issue Date
2015
MeSH
Aged ; Aged, 80 and over ; Aging/metabolism* ; Aging/psychology ; Asian Continental Ancestry Group* ; Biomarkers/metabolism ; C-Reactive Protein/metabolism* ; Comorbidity ; Depression/epidemiology ; Depression/metabolism* ; Female ; Health Surveys ; Humans ; Inflammation/metabolism* ; Inflammation/psychology ; Longitudinal Studies ; Male ; Odds Ratio ; Republic of Korea/epidemiology ; Risk Factors ; Rural Population ; Socioeconomic Factors ; Surveys and Questionnaires
Keywords
GERIATRIC MEDICINE
Abstract
OBJECTIVE: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. DESIGN, SETTING AND PARTICIPANTS: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. RESULTS: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. CONCLUSIONS: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.
Files in This Item:
T201500554.pdf Download
DOI
10.1136/bmjopen-2014-006429
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Ju Mi(이주미)
Choi, Wungrak(최웅락) ORCID logo https://orcid.org/0000-0002-3015-2502
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139544
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