Cited 67 times in

Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation

Authors
 Hyung Jung Oh  ;  Bo Young Nam  ;  Mi Jung Lee  ;  Chan Ho Kim  ;  Hyang Mo Koo  ;  Fa Mee Doh  ;  Jae Hyun Han  ;  Eun Jin Kim  ;  Ji Suk Han  ;  Jung Tak Park  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Dae-Suk Han  ;  Seung Hyeok Han 
Citation
 PERITONEAL DIALYSIS INTERNATIONAL, Vol.35(1) : 43-51, 2015 
Journal Title
PERITONEAL DIALYSIS INTERNATIONAL
ISSN
 0896-8608 
Issue Date
2015
MeSH
Biomarkers/blood ; C-Reactive Protein/metabolism* ; Cross-Sectional Studies ; Dinoprost/analogs & derivatives* ; Dinoprost/metabolism ; Female ; Follow-Up Studies ; Glucuronidase/metabolism* ; Humans ; Inflammation/physiopathology ; Interleukin-6/metabolism* ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy* ; Male ; Oxidative Stress/physiology ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/methods* ; Predictive Value of Tests ; Risk Assessment ; Survival Rate ; Treatment Outcome
Keywords
ESRD ; inflammation ; klotho ; oxidative stress
Abstract
INTRODUCTION: It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with endstage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD.
METHODS: We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman's correlation coefficients for between co-variates and conducted multiple linear regression analyses.
RESULTS: Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (γ = -0.310, p = 0.006) and log IL-6 (γ = -0.343, p = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (β = -0.158, p = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model.
CONCLUSIONS: This study showed that circulating klotho levels were significantly associated with 8-isoprostane levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients.
Full Text
http://www.pdiconnect.com/content/35/1/43.abstract
DOI
10.3747/pdi.2013.00150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Koo, Hyang Mo(구향모)
Kim, Eun Jin(김은진)
Kim, Chan Ho(김찬호)
Nam, Bo Young(남보영)
Doh, Fa Mee(도화미) ORCID logo https://orcid.org/0000-0002-4780-6728
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
Han, Jae Hyun(한재현)
Hahn, Jee Sook(한지숙)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139491
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links