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Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation

Authors
 Hyung Jung Oh  ;  Bo Young Nam  ;  Mi Jung Lee  ;  Chan Ho Kim  ;  Hyang Mo Koo  ;  Fa Mee Doh  ;  Jae Hyun Han  ;  Eun Jin Kim  ;  Ji Suk Han  ;  Jung Tak Park  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Dae-Suk Han  ;  Seung Hyeok Han 
Citation
 Peritoneal Dialysis International, Vol.35(1) : 43-51, 2015 
Journal Title
 Peritoneal Dialysis International 
ISSN
 0896-8608 
Issue Date
2015
Abstract
INTRODUCTION: It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with endstage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD. METHODS: We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman's correlation coefficients for between co-variates and conducted multiple linear regression analyses. RESULTS: Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (γ = -0.310, p = 0.006) and log IL-6 (γ = -0.343, p = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (β = -0.158, p = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model. CONCLUSIONS: This study showed that circulating klotho levels were significantly associated with 8-isoprostane levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients.
Full Text
http://www.pdiconnect.com/content/35/1/43.abstract
DOI
10.3747/pdi.2013.00150
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
구향모(Koo, Hyang Mo)
김은진(Kim, Eun Jin)
김찬호(Kim, Chan Ho)
남보영(Nam, Bo Young)
도화미(Doh, Fa Mee) ORCID logo https://orcid.org/0000-0002-4780-6728
박정탁(Park, Jung Tak) ORCID logo https://orcid.org/0000-0002-2325-8982
오형중(Oh, Hyung Jung)
유태현(Yoo, Tae Hyun) ORCID logo https://orcid.org/0000-0002-9183-4507
이미정(Lee, Mi Jung)
한대석(Han, Dae Suk)
한승혁(Han, Seung Hyeok) ORCID logo https://orcid.org/0000-0001-7923-5635
한재현(Han, Jae Hyun)
한지숙(Hahn, Jee Sook)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139491
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