Cited 62 times in
Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation
DC Field | Value | Language |
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dc.contributor.author | 김찬호 | - |
dc.contributor.author | 남보영 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 한재현 | - |
dc.contributor.author | 한지숙 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 김은진 | - |
dc.date.accessioned | 2016-02-04T11:01:21Z | - |
dc.date.available | 2016-02-04T11:01:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0896-8608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139491 | - |
dc.description.abstract | INTRODUCTION: It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with endstage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD. METHODS: We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman's correlation coefficients for between co-variates and conducted multiple linear regression analyses. RESULTS: Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (γ = -0.310, p = 0.006) and log IL-6 (γ = -0.343, p = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (β = -0.158, p = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model. CONCLUSIONS: This study showed that circulating klotho levels were significantly associated with 8-isoprostane levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 43~51 | - |
dc.relation.isPartOf | PERITONEAL DIALYSIS INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Dinoprost/analogs & derivatives* | - |
dc.subject.MESH | Dinoprost/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glucuronidase/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/physiopathology | - |
dc.subject.MESH | Interleukin-6/metabolism* | - |
dc.subject.MESH | Kidney Failure, Chronic/diagnosis | - |
dc.subject.MESH | Kidney Failure, Chronic/mortality | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Peritoneal Dialysis/adverse effects | - |
dc.subject.MESH | Peritoneal Dialysis/methods* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Bo Young Nam | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Jae Hyun Han | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Ji Suk Han | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Dae-Suk Han | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.3747/pdi.2013.00150 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01251 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A04320 | - |
dc.contributor.localId | A04327 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A00823 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J02500 | - |
dc.identifier.eissn | 1718-4304 | - |
dc.identifier.pmid | 24497597 | - |
dc.identifier.url | http://www.pdiconnect.com/content/35/1/43.abstract | - |
dc.subject.keyword | ESRD | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | klotho | - |
dc.subject.keyword | oxidative stress | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Nam, Bo Young | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Han, Jae Hyun | - |
dc.contributor.alternativeName | Hahn, Jee Sook | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Nam, Bo Young | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Han, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | PERITONEAL DIALYSIS INTERNATIONAL, Vol.35(1) : 43-51, 2015 | - |
dc.identifier.rimsid | 55427 | - |
dc.type.rims | ART | - |
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